Комбінована терапія ішемічної хвороби серця Армадіном і Тризипіном — ще один варіант або унікальна можливість?
| العنوان: | Комбінована терапія ішемічної хвороби серця Армадіном і Тризипіном — ще один варіант або унікальна можливість? |
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| المؤلفون: | S.O. Andriievska, H.O. Bezsmertna |
| المصدر: | HYPERTENSION. :49-57 |
| بيانات النشر: | Publishing House Zaslavsky, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | medicine.medical_specialty, Rehabilitation, Evening, Combination therapy, business.industry, medicine.medical_treatment, 030204 cardiovascular system & hematology, Ventricular tachycardia, medicine.disease, 03 medical and health sciences, Regimen, 0302 clinical medicine, Physical therapy, medicine, Outpatient clinic, 030212 general & internal medicine, Treadmill, business, Morning |
| الوصف: | Background. The article presents the data of the COMETA study on the effectiveness of the combination of Armadin + Trizipin preparations, injection and tablet forms, by the domestic manufacturer Microkhim Research and Production Company, Ltd, in the comprehensive treatment of patients with ischemic heart disease (IHD) and high cardiovascular risk (HCR) in a day cardiology hospital and outpatient clinic, provides an integral evaluation of the validity of using the developed treatment regimen for a month and during long-term follow-up. Materials and methods. The study included 30 patients with IHD and HCR who received standard therapy according to the ESC recommendation. In addition, i.v. drip infusions of Armadin (200 mg per 100.0 saline solution), Trizipin (1000 mg i.v. in the tube at 1 : 2 dilution in saline solution), Armadin long 300 mg, 1 tablet in the evening — for two weeks, then during four weeks Trizipin long 1000 mg in the morning, Armadin long 300 mg, 1 tablet in the morning and in the evening were administered. The efficiency of the prescribed complex was monitored by the dynamics of clinical status, treadmill test (t/test), 6-minute walk test, echocardioscopy, Holter ECG monitoring (HECGM) using standard techniques; self-evaluation of the quality of life was carried out according to the classic questionnaire using the MOS 36-Item Short-Form Health Survey (SF-36). Results. We have established a positive dynamics in the clinical state of patients, the prevalence of statistically reliable indicators of objective researches: t/test — an increase in the tolerance to physical activity by 3.4 МЕТ, an increase in the distance traveled during 6-minute walk test and transition of 33.3 % of patients into the category of persons with a mild functional class of the disease, a decrease in the number of atrial and ventricular extrasystoles in HECGM and, most importantly, the elimination of short paroxysms of ventricular tachycardia. The questioning of patients with regard to the dynamics of the quality of life assessment showed a positive result in the basic criteria of the questionnaire: role functioning conditioned by the physical and emotional state improved by half (before and after — 50 and 100, 33 and 67, respectively). Conclusions. Comprehensive treatment with Armadin and Trizipin preparations (injection, tablet form) is a successful technology of therapy and rehabilitation of patients with IHD and HCR. Further long-term observations with long-term use of the technique in a permanent regimen are worthwhile. The combination of Armadin + Trizipin preparations by the domestic manufacturer Microkhim Research and Production Company, Ltd is promising in terms of active study as a part of the comprehensive therapy of IHD patients and introduction into a wide medical practice with the purpose of increasing therapeutic effectiveness. |
| تدمد: | 2307-1095 2224-1485 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::24498571cafde75834ec265e34b3ac75Test https://doi.org/10.22141/2224-1485.4.54.2017.109543Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi...........24498571cafde75834ec265e34b3ac75 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23071095 22241485 |
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