Abstract WMP13: Delayed Stimulation Of Angiotensin II Type 2 Receptor Ameliorates Sensorimotor Deficits And Cognitive Decline After Stroke In Aged Hypertensive Rats
| العنوان: | Abstract WMP13: Delayed Stimulation Of Angiotensin II Type 2 Receptor Ameliorates Sensorimotor Deficits And Cognitive Decline After Stroke In Aged Hypertensive Rats |
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| المؤلفون: | Abdulkarim Alshammari, Tim W Jones, Bindu Pillai, Pradip Kamat, Mohammad B Khan, David C Hess, Asamoah Bosomtwi, Adviye Ergul, Susan C Fagan |
| المصدر: | Stroke. 53 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Advanced and Specialized Nursing, Neurology (clinical), Cardiology and Cardiovascular Medicine |
| الوصف: | Hypertension and aging are leading risk factors for stroke and cognitive decline. Animal models fail to capture the complex interplay between these two pathophysiologic processes, limiting human translation of interventions. In the current study, we investigated the development of cognitive impairment in 18-month-old spontaneously hypertensive rats (SHRs) prior to and following a 30-minute tMCAO or SHAM. Sixty SHRs were kept for 18 months with cognitive assessments performed prior to and post-surgery. Baseline brain MRI was done at 18 months and then at day 3 and week 8 post-surgery. At day 3, rats were randomly assigned to blindly receive either C21 or normal drinking water for 8 weeks. Results: Over 18 months, SHRs demonstrated a progressive cognitive decline and significant abnormalities on MRI. Aged SHRs demonstrated an acceptably low 14% peri-operative mortality within 72 hours of tMCAO. Stroke resulted in sustained, significant sensorimotor deficits and C21 effectively enhanced sensorimotor recovery at week 8. Progressive cognitive decline continued after surgery, but C21 enhanced post-stroke, subacute associative and reference memory at week 5. There was no evidence of anhedonia at 8 weeks. MRI scans revealed no difference in ischemic lesion resolution between C21 and control. However, C21 treated rats had less cortical atrophy and reduced WM injury at 8 weeks. Conclusions: Aged SHRs with minor stroke demonstrated persistent sensorimotor deficits, which were significantly lessened with C21. The dramatic decline in exploration time with age was ameliorated with C21 treatment, evidence of preserved cognition. |
| تدمد: | 1524-4628 0039-2499 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::241b151efeaa1eab57c05119b44cff6fTest https://doi.org/10.1161/str.53.suppl_1.wmp13Test |
| رقم الانضمام: | edsair.doi...........241b151efeaa1eab57c05119b44cff6f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15244628 00392499 |
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