To observe the clinical effect of combined laparoscopic and choledochoscopic surgery for gallbladder combined with common bile duct stones. A total of 102 patients with gallbladder stones combined with common bile duct stones admitted to our hospital between January 2017 and December 2020 were selected and randomly divided into 51 cases in the study group and 51 cases in the control group. The control group was treated with laparoscopic gallbladder stones treatment and the trial group was treated with laparoscopic combined with choledochoscopic surgery. The surgery-related indexes, serum inflammatory indexes and postoperative complications of patients in the two groups were compared, as well as the treatment efficiency. After treatment, the intraoperative bleeding, average postoperative hospitalization time, 24 h postoperative visual analogue scale score and time to first postoperative venting of patients in the laparoscopic group were significantly better than those in the control group, but the operative time was significantly more than that in the control group and the difference was statistically significant (p 0.05); 1 d after surgery, the serum procalcitonin and high-sensitivity C-reactive protein levels of the two groups were lower than those before surgery and the study group was significantly lower than the control group and the difference was statistically significant (p 0.05). The total complication rate of the test group was lower than that of the control group (p
