Fatty acid-binding protein 4: a key regulator of ketoacidosis in new-onset type 1 diabetes
| العنوان: | Fatty acid-binding protein 4: a key regulator of ketoacidosis in new-onset type 1 diabetes |
|---|---|
| المؤلفون: | Noah Gruber, Ehud Barhod, Orit Pinhas-Hamiel, Sharon Sheinvald, Amir Tirosh, Moran Rathaus, Rina Hemi, Idit Ron, Amit Tirosh, Rinat Livne |
| المصدر: | Diabetologia. 65:366-374 |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Type 1 diabetes, medicine.medical_specialty, Diabetic ketoacidosis, business.industry, Endocrinology, Diabetes and Metabolism, Insulin, medicine.medical_treatment, medicine.disease, Ketoacidosis, NEFA, Endocrinology, Blood chemistry, Diabetes mellitus, Internal medicine, Ketogenesis, Internal Medicine, medicine, business |
| الوصف: | Fatty acid-binding protein 4 (FABP4) is an adipokine with a key regulatory role in glucose and lipid metabolism. We prospectively evaluated the role of FABP4 in the pathophysiology of diabetic ketoacidosis (DKA) in new-onset type 1 diabetes. Clinical and laboratory data were prospectively collected from consecutive children presenting with new-onset type 1 diabetes. In addition to blood chemistry and gases, insulin, C-peptide, serum FABP4 and NEFA were collected upon presentation and 48 h after initiation of insulin treatment. In a mouse model of type 1 diabetes, glucose, insulin, β-hydroxybutyrate and weight were compared between FABP4 knockout (Fabp4−/−) and wild-type (WT) mice. Included were 33 children (mean age 9.3 ± 3.5 years, 52% male), of whom 14 (42%) presented with DKA. FABP4 levels were higher in the DKA group compared with the non-DKA group (median [IQR] 10.1 [7.9–14.2] ng/ml vs 6.3 [3.9–7] ng/ml, respectively; p = 0.005). The FABP4 level was positively correlated with HbA1c at presentation and inversely correlated with venous blood pH and bicarbonate levels (p |
| تدمد: | 1432-0428 0012-186X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::17a8a530c5b1d22e5572190650dbc96cTest https://doi.org/10.1007/s00125-021-05606-0Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi...........17a8a530c5b1d22e5572190650dbc96c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14320428 0012186X |
|---|