Haemolytic uraemic syndrome following bone marrow transplantation. Case report and review of the literature
| العنوان: | Haemolytic uraemic syndrome following bone marrow transplantation. Case report and review of the literature |
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| المؤلفون: | Cornelis A. Verburgh, S. Van Veen, C. G. Vermeij, J. M. J. M. Zijlmans, L. A. Van Es |
| المصدر: | Nephrology Dialysis Transplantation. 11:1332-1337 |
| بيانات النشر: | Oxford University Press (OUP), 1996. |
| سنة النشر: | 1996 |
| مصطلحات موضوعية: | Hemolytic anemia, Transplantation, medicine.medical_specialty, Thrombotic microangiopathy, business.industry, medicine.medical_treatment, Total body irradiation, medicine.disease, Gastroenterology, Surgery, Sepsis, surgical procedures, operative, medicine.anatomical_structure, immune system diseases, Nephrology, hemic and lymphatic diseases, Cyclosporin a, Internal medicine, medicine, Hemodialysis, Bone marrow, Complication, business |
| الوصف: | Thrombotic microangiopathy (TMA) can be a late complication of bone marrow transplantation (BMT). A patient is described in whom the haemolytic uraemic syndrome developed 10 months after BMT and who died of E. coli sepsis while on maintenance haemodialysis. The literature is reviewed, regarding clinical presentation, incidence, pathogenesis and therapy. TMA can be observed, after an interval of 3-12 months, in about 6-26% of patients following BMT. Reported cases vary considerably in clinical severity, from mild presentations to severe TMA with high mortality rates despite intensive therapy. Important pathogenetic roles are ascribed to the conditioning total body irradiation and the use of cyclosporin A, but other factors may be involved as well. Next to supportive therapy, plasma exchange and the use of ACE inhibitors may be of value in treating BMT-associated TMA. |
| تدمد: | 1460-2385 0931-0509 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::1460648dd4568c23162995d3e0b8b403Test https://doi.org/10.1093/ndt/11.7.1332Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi...........1460648dd4568c23162995d3e0b8b403 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14602385 09310509 |
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