Long-term oncologic outcomes of liver resection for hepatocellular carcinoma in adolescents and young adults: A multicenter study from a hepatitis B virus-endemic area
| العنوان: | Long-term oncologic outcomes of liver resection for hepatocellular carcinoma in adolescents and young adults: A multicenter study from a hepatitis B virus-endemic area |
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| المؤلفون: | Ting-Hao Chen, Yong-Kang Diao, Tian Yang, Ying-Jian Liang, Wei-Min Gu, Jie Li, Ya-Hao Zhou, Hong Wang, Wan Yee Lau, Xin-Ping Fan, Jun-Wei Liu |
| المصدر: | Annals of Hepato-Biliary-Pancreatic Surgery. 25:S241-S241 |
| بيانات النشر: | The Korean Association of Hepato-Biliary-Pancreatic Surgery, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Hepatitis B virus, medicine.medical_specialty, Cirrhosis, business.industry, Incidence (epidemiology), Hazard ratio, Perioperative, medicine.disease, medicine.disease_cause, Gastroenterology, humanities, Internal medicine, Hepatocellular carcinoma, Medicine, Portal hypertension, General Materials Science, Young adult, business |
| الوصف: | Introduction Hepatocellular carcinoma (HCC) is common among adolescents and young adults (AYAs) with chronic hepatitis B virus (HBV) infection in areas with endemic HBV. We sought to characterize clinical features and long-term oncologic outcomes among AYAs versus older adults (OAs) who underwent liver resection for HCC. Methods Patients undergoing curative-intent liver resection for HCC were identified using a Chinese multicenter database; patients were categorized as AYA (aged 13-39 years) versus OA (aged ≥ 40 years). Patient clinical features, perioperative outcomes, overall survival (OS) and time-to-recurrence (TTR) were evaluated and compared. Multivariable Cox-regression analyses were performed to identify the impact of age relative to the risk factors associated with OS and TTR. Results Among 1,952 patients with HCC who underwent resection, 354 (22.2%) were AYAs. AYAs were less likely to have cirrhosis or portal hypertension yet were likely to have advanced tumor pathological characteristics than OAs. Although major hepatectomy was more often performed in the AYA group, postoperative morbidity and mortality were comparable between the AYA and OA groups. Compared with OAs, the AYAs had a comparable OS (median: 88.8 vs. 93.2 months, p = 0.305) but a decreased TTR (median: 35.6 vs. 50.7 months, p = 0.029). After adjustment for other confounding factors on multivariable analyses, young age (< 40 years) was independently associated with poorer TTR (hazard ratio: 1.35, 95% confidence interval: 1.08-1.69, p = 0.009) but not OS (p = 0.15). Conclusions Compared with OAs, AYAs had a higher incidence of recurrence following liver resection among Chinese patients with HCC, suggesting that enhanced surveillance for postoperative recurrence may be required among. |
| تدمد: | 2508-5859 2508-5778 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::12ac3ccbf2d2e3ee60f501776f98c809Test https://doi.org/10.14701/ahbps.ep-40Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi...........12ac3ccbf2d2e3ee60f501776f98c809 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 25085859 25085778 |
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