Metabolism of Phenanthrene, Benz[a]anthracene, Benzo[a]pyrene, Chrysene and Benzo[c]phenanthrene by Eight cDNA-expressed Human and Rat Cytochromes P450
| العنوان: | Metabolism of Phenanthrene, Benz[a]anthracene, Benzo[a]pyrene, Chrysene and Benzo[c]phenanthrene by Eight cDNA-expressed Human and Rat Cytochromes P450 |
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| المؤلفون: | Volker J. Soballa, Gernot Grimmer, Jürgen Jacob, Gottfried Raab, Helmut Greim, Johannes Doehmer, Albrecht Seidel |
| المصدر: | Polycyclic Aromatic Compounds. 10:1-9 |
| بيانات النشر: | Informa UK Limited, 1996. |
| سنة النشر: | 1996 |
| مصطلحات موضوعية: | Chrysene, Anthracene, Polymers and Plastics, Stereochemistry, Organic Chemistry, Benzo(c)phenanthrene, CYP1A2, respiratory system, Phenanthrene, Benz(a)anthracene, chemistry.chemical_compound, Benzo(a)pyrene, chemistry, polycyclic compounds, Materials Chemistry, Pyrene, heterocyclic compounds |
| الوصف: | Phenanthrene, benz[a]anthracene, chrysene, benzo[c]phenanthrene, and benzo[a]pyrene have been studied for their regiospecific oxidation by five human (1A1, 1A2, 2A6, 2E1, 3A4) and three rat (1A1, 1A2, 2B1) CYP isoforms. All substrates are preferentially metabolized by CYP1A1 and CYP1A2 in human and rat. Other isoforms play a minor role if at all. Significant differences between human and rat CYP isoforms can be recognized with regard to the regiospecific oxidation of PAH. For instance, K-region oxidation is more pronounced in rat than in human CYP1A1 and CYP1A2. Hence, extrapolation from metabolism studies in rodents to human may be limited. |
| تدمد: | 1563-5333 1040-6638 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::11876bd474c9098fc074e92864cb3a9dTest https://doi.org/10.1080/10406639608034673Test |
| رقم الانضمام: | edsair.doi...........11876bd474c9098fc074e92864cb3a9d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15635333 10406638 |
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