A RANDOMIZED, DOUBLE-BLIND, DOUBLE-DUMMY, CONTROLLED DOSE COMPARISON OF THALIDOMIDE FOR TREATMENT OF ERYTHEMA NODOSUM LEPROSUM
| العنوان: | A RANDOMIZED, DOUBLE-BLIND, DOUBLE-DUMMY, CONTROLLED DOSE COMPARISON OF THALIDOMIDE FOR TREATMENT OF ERYTHEMA NODOSUM LEPROSUM |
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| المؤلفون: | Tranquilino T. Fajardo, Esterlina V. Tan, Maria V. Balagon, R. V. Cellona, Janet Wittes, Laarni G. Villahermosa, Jeffrey P. Palmer, Rodolfo M. Abalos, Gerald P. Walsh, Douglas S. Walsh, Steven D. Thomas, Karin A. Kook |
| المصدر: | The American Journal of Tropical Medicine and Hygiene. 72:518-526 |
| بيانات النشر: | American Society of Tropical Medicine and Hygiene, 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | medicine.medical_specialty, Chemotherapy, Every Two Weeks, business.industry, medicine.medical_treatment, Group A, Gastroenterology, Group B, law.invention, Surgery, Discontinuation, Thalidomide, Infectious Diseases, Randomized controlled trial, law, Virology, Internal medicine, Medicine, Parasitology, business, medicine.drug, Antibacterial agent |
| الوصف: | In a randomized, double-blind, double-dummy controlled study, 22 men with erythema nodosum leprosum (ENL) received six capsules containing either 100 mg (group A, n = 12) or 300 mg (group B, n = 10) of thalidomide daily for one week. A six-week, four capsules per day taper followed, in which group A received 50 mg/day of thalidomide in weeks 2 and 3, then dummy capsules in weeks 4 through 7, while group B had gradual decrements every two weeks. Both regimens caused comparable improvement in 19 patients at day 7 (group A [12 of 12] versus group B [7 of 10]; P = 0.08), but slower tapering in group B showed less re-emergence of ENL through week 7 (P = 0.02, versus group A). Most patients developed new lesions soon after stopping treatment. Slower tapering from a higher initial thalidomide dose may improve clinical ENL responses, but high recurrence rates after discontinuation indicates further assessment is needed to identify better tapering regimens. |
| تدمد: | 1476-1645 0002-9637 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::10390464525c888ca1c1503ff6016b1cTest https://doi.org/10.4269/ajtmh.2005.72.518Test |
| رقم الانضمام: | edsair.doi...........10390464525c888ca1c1503ff6016b1c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14761645 00029637 |
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