A novel approach for targeting the left dorsolateral prefrontal cortex for transcranial magnetic stimulation using a cognitive task
| العنوان: | A novel approach for targeting the left dorsolateral prefrontal cortex for transcranial magnetic stimulation using a cognitive task |
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| المؤلفون: | Adriano H. Moffa, Colleen Loo, Stevan Nikolin, Ashley Wang, Donel Martin |
| المصدر: | Experimental Brain Research. 240:71-80 |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, Neurology, business.industry, General Neuroscience, medicine.medical_treatment, Stimulation, Cognition, behavioral disciplines and activities, Crossover study, Task (project management), Dorsolateral prefrontal cortex, Transcranial magnetic stimulation, Physical medicine and rehabilitation, medicine.anatomical_structure, nervous system, mental disorders, Medicine, Cognitive skill, business, psychological phenomena and processes |
| الوصف: | Repetitive transcranial magnetic stimulation (rTMS) has the potential to be developed as a novel treatment for cognitive dysfunction. However, current methods of targeting rTMS for cognition fail to consider inter-individual functional variability. This study explored the use of a cognitive task to individualise the target site for rTMS administered to the left dorsolateral prefrontal cortex (L-DLPFC). Twenty-five healthy participants were enrolled in a sham-controlled, crossover study. Participants performed a random letter generation task under the following conditions: no stimulation, sham and active ‘online’ rTMS applied to F3 (International 10–20 System) and four standardised surrounding sites. Across all sites combined, active ‘online’ rTMS was associated with significantly reduced performance compared to sham rTMS for unique trigrams (p = 0.012), but not for unique digrams (p > 0.05). Using a novel localisation methodology based on performance outcomes from both measures, a single optimal individualised site was identified for 92% [n = 23] of participants. At the individualised site, performance was significantly poorer compared to a common standard site (F3) and both control conditions (ps |
| تدمد: | 1432-1106 0014-4819 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::0eaac3ee519cdd8a8d1674c7d63af303Test https://doi.org/10.1007/s00221-021-06233-2Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi...........0eaac3ee519cdd8a8d1674c7d63af303 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14321106 00144819 |
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