Binding of Benzo[a]pyrene Alters the Bioreactivity of Fine Biochar Particles toward Macrophages Leading to Deregulated Macrophagic Defense and Autophagy
| العنوان: | Binding of Benzo[a]pyrene Alters the Bioreactivity of Fine Biochar Particles toward Macrophages Leading to Deregulated Macrophagic Defense and Autophagy |
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| المؤلفون: | Jiahuang Qiu, Wei Chen, Sijin Liu, Yi Y. Zuo, Yi Yang, Xinlei Liu, Juan Ma, Quanzhong Ren, Zheng Dong, Tian Xia |
| المصدر: | ACS Nano. 15:9717-9731 |
| بيانات النشر: | American Chemical Society (ACS), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Innate immune system, Chemistry, Autophagy, General Engineering, General Physics and Astronomy, 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, Endocytosis, medicine.disease_cause, 01 natural sciences, 0104 chemical sciences, Cell biology, Proinflammatory cytokine, chemistry.chemical_compound, Benzo(a)pyrene, Toxicity, medicine, General Materials Science, 0210 nano-technology, Cytotoxicity, Oxidative stress |
| الوصف: | Contaminant-bearing fine biochar particles (FBPs) may exert significantly different toxicity profiles from their contaminant-free counterparts. While the role of FBPs in promoting contaminant uptake has been recognized, it is unclear whether the binding of contaminants can modify the biochemical reactivity and toxicological profiles of FBPs. Here, we show that binding of benzo[a]pyrene (B(a)P, a model polycyclic aromatic hydrocarbon) at environmentally relevant exposure concentrations markedly alters the cytotoxicity of FBPs to macrophages, an important line of innate immune defense against airborne particulate matters (PMs). Specifically, B(a)P-bearing FBPs elicit more severe disruption of the phospholipid membrane, endocytosis, oxidative stress, autophagy, and compromised innate immune defense, as evidenced by blunted proinflammatory effects, compared with B(a)P-free FBPs. Notably, the altered cytotoxicity cannot be attributed to the dissolution of B(a)P from the B(a)P-bearing FBPs, but appears to be related to B(a)P adsorption-induced changes of FBPs bioreactivity toward macrophages. Our findings highlight the significance of environmental chemical transformation in altering the bioreactivity and toxicity of PMs and call for further studies on other types of carbonaceous nanoparticles and additional exposure scenarios. |
| تدمد: | 1936-086X 1936-0851 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::0b6e6610b289f5e7e168bc4e8f5cd75cTest https://doi.org/10.1021/acsnano.1c00324Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi...........0b6e6610b289f5e7e168bc4e8f5cd75c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1936086X 19360851 |
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