Glycemic Variability from CGM Correlates with Indices of Glucose Metabolism in Healthy Obesity but Not in Type 2 Diabetes
| العنوان: | Glycemic Variability from CGM Correlates with Indices of Glucose Metabolism in Healthy Obesity but Not in Type 2 Diabetes |
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| المؤلفون: | Renata Belfort-DeAguiar, Wai Lam, Janice Hwang, Ahmed Elshafie, Christian P. Schmidt, Lisa Parikh, Robert S. Sherwin, Elizabeth Sanchez Rangel, Catherine W. Yeckel |
| المصدر: | Diabetes. 67 |
| بيانات النشر: | American Diabetes Association, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | medicine.medical_specialty, endocrine system diseases, business.industry, Endocrinology, Diabetes and Metabolism, Insulin, medicine.medical_treatment, nutritional and metabolic diseases, Type 2 diabetes, Carbohydrate metabolism, medicine.disease, Obesity, Metformin, Endocrinology, Insulin resistance, Diabetes mellitus, Internal medicine, Internal Medicine, Medicine, business, Glycemic, medicine.drug |
| الوصف: | We evaluated the relationship between measurements of beta cell function and insulin resistance assessed from OGTT and 2-step glucose clamp data with indices of glucose variability (GV) obtained with a continuous glucose monitor (CGM) in obese subjects with and without type 2 diabetes (T2D). 17 healthy obese (OB) (FPG 91 ± 4.9mg/dl and A1c 5.2 ± 0.4%) and 8 age- and weight-matched participants with T2D treated with diet and/or metformin (FPG 131.5 ± 42.8 mg/dl and A1c 6.8 ± 0.8%) wore CGM (Dexcom®) for up to 5 days. EasyGV® software was used to calculate indices of GV: standard deviation (SD), mean amplitude of glycemic excursions (MAGE), J-Index, continuous overlapping net glycemic action (CONGA), and Glycemic Risk Assessment in Diabetes Equation (GRADE). Indices of glucose metabolism were determined with a 2 hour OGTT and a two-step hyperglycemic-euglycemic clamp. Insulin levels during the hyperglycemic-step of clamp (116 ± 126 vs. 40 ± 23 mU/mL) were equal in both groups, while glucose infusion rate (GIR) (7.7 ± 3.1 vs. 3.9 ± 2.4 mg/kg/minutes) during euglycemia was as expected significantly lower in the T2D subjects compared to OB subjects. GV indices (SD, CONGA, J-Index, GRADE) were statistically lower in OB vs. T2D (P Disclosure A. Elshafie: None. W. Lam: None. L. Parikh: None. E. Sanchez Rangel: None. C.P. Schmidt: None. J. Hwang: None. C.W. Yeckel: None. R. Sherwin: Other Relationship; Self; QuintilesIMS, MannKind Corporation. Research Support; Self; Regeneron Pharmaceuticals, Inc.. Other Relationship; Self; ICON plc. R. Belfort-DeAguiar: Research Support; Self; GlaxoSmithKline plc.. |
| تدمد: | 1939-327X 0012-1797 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::0898ea0407a54dd377cf832bde371558Test https://doi.org/10.2337/db18-82-lbTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi...........0898ea0407a54dd377cf832bde371558 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1939327X 00121797 |
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