Studies on a Mechanism of Superoxide Production Catalyzed by Phagocytic Cytochrome b
| العنوان: | Studies on a Mechanism of Superoxide Production Catalyzed by Phagocytic Cytochrome b |
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| المؤلفون: | Yasuhiro Isogai, Tetsutaro Iizuka |
| المصدر: | Seibutsu Butsuri. 34:117-123 |
| بيانات النشر: | Biophysical Society of Japan, 1994. |
| سنة النشر: | 1994 |
| مصطلحات موضوعية: | Hemeprotein, biology, Biochemistry, Cytochrome C1, Cytochrome, Chemistry, Cytochrome c peroxidase, Cytochrome c, Coenzyme Q – cytochrome c reductase, biology.protein, Cytochrome c oxidase, Cytochrome P450 reductase |
| الوصف: | Phagocytic cytochrome b558 is a membrane-bound heme-containing enzyme that catalyzes one-electron reduction of O2 to produce superoxide anion. This cytochrome b has a low-spin 6-coordinate heme iron, and its catalytic activity is not inhibited by respiratory inhibitors such as CO. In this paper, the recent progress is reviewed focusing on the structure and the function of the cytochrome. Our spectroscopic and kinetic data suggest that cytochrome b558 catalyzes the O2- production without ligation of O2 to the heme iron during the catalytic cycle. The mechanisms of oxygen reduction and regulation of the electron transfer reactions are discussed. |
| تدمد: | 1347-4219 0582-4052 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::039927130681845a2e400a624bf166ecTest https://doi.org/10.2142/biophys.34.117Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi...........039927130681845a2e400a624bf166ec |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13474219 05824052 |
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