Human metapneumovirus genotypes and Severity of disease in children during a 7-year study in Dijon, France
| العنوان: | Human metapneumovirus genotypes and Severity of disease in children during a 7-year study in Dijon, France |
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| المؤلفون: | Pitoiset, Cécile, Darniot, Magali, Huet, Frédéric, Aho, Serge-Ludwig, Pothier, Pierre, Manoha, Catherine |
| المساهمون: | Laboratoire de sérologie-virologie (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Service de pédiatrie (CHU de Dijon), Service d'épidémiologie et d'hygiène hospitalières (CHU de Dijon) |
| المصدر: | Journal of Medical Virology Journal of Medical Virology, Wiley-Blackwell, 2010, 82 (10), pp.1782. ⟨10.1002/jmv.21884⟩ |
| بيانات النشر: | HAL CCSD, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Medicine |
| الوصف: | International audience; Human metapneumovirus is a cause of respiratory tract infections at all ages. Our objectives were to analyze the distribution of the A and B genotypes over seven years in Dijon and to investigate a possible association between hMPV genotypes and disease severity. During 2002-2009, we genotyped 100 isolates from children less than three years old with hMPV. Phylogenetic analysis indicated a change in the distribution of hMPV genotype over the years. Severity was then measured by detailed clinical evaluation. The hospitalization rate was greater when genotype B was involved 72.5% vs. 53.3% (p = 0.054). Those infected with genotype B tended to have a higher clinical score, as measured by Vicente et al, 2006, (p = 0.07). We showed that, although clinical severity is not clearly associated with hMPV genotype, pathological signs on chest X-ray were observed more often in B subgroup (p |
| اللغة: | English |
| تدمد: | 0146-6615 1096-9071 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::507c4fcf25716509caf75b67bf9b758eTest https://hal.archives-ouvertes.fr/hal-00570701Test |
| رقم الانضمام: | edsair.dedup.wf.001..507c4fcf25716509caf75b67bf9b758e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 01466615 10969071 |
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