Axonal Control of the Adult Neural Stem Cell Niche
| العنوان: | Axonal Control of the Adult Neural Stem Cell Niche |
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| المؤلفون: | Tong CK, Chen J, Cebrian-Silla A, Mirzadeh Z, Obernier K, Guinto CD, Tecott LH, Garcia-Verdugo JM, Kriegstein A, Alvarez-Buylla A |
| المصدر: | Cell Stem Cell r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe instname |
| بيانات النشر: | CELL PRESS, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | nervous system |
| الوصف: | The ventricular-subventricular zone (V-SVZ) is an extensive germinal niche containing neural stem cells (NSCs) in the walls of the lateral ventricles of the adult brain. How the adult brain's neural activity influences the behavior of adult NSCs remains largely unknown. We show that serotonergic (5HT) axons originating from a small group of neurons in the raphe form an extensive plexus on most of the ventricular walls. Electron microscopy revealed intimate contacts between 5HT axons and NSCs (B1) or ependymal cells (E1) and these cells were labeled by a transsynaptic viral tracer injected into the raphe. B1 cells express the 5HT receptors 2C and 5A. Electrophysiology showed that activation of these receptors in B1 cells induced small inward currents. Intraventricular infusion of 5HT2C agonist or antagonist increased or decreased V-SVZ proliferation, respectively. These results indicate that supraependymal 5HT axons directly interact with NSCs to regulate neurogenesis via 5HT2C. |
| تدمد: | 1934-5909 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::faeeed5906e81ec2060ec34e47db33bdTest https://fundanet.iislafe.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=9796Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.RECOLECTA.....faeeed5906e81ec2060ec34e47db33bd |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19345909 |
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