Evaluation of serum visfatin in children and adolescent with Type 1 diabetes mellitus
العنوان: | Evaluation of serum visfatin in children and adolescent with Type 1 diabetes mellitus |
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المؤلفون: | Khater, Nahed Mahmoud, ELrahman, Hadeel Mohammed Abd, Mohammed, Randa Hussieny, Elashery, Mahmoud Ali |
المصدر: | Egyptian Journal of Hospital Medicine; Vol. 86 No. 1 (2022); 324-328 |
بيانات النشر: | Ain Shams University, 2022. |
سنة النشر: | 2022 |
مصطلحات موضوعية: | Visfatin, Pediatric, Type1 Diabetes mellitus, Assessment, endocrine system diseases |
الوصف: | Background: Type 1 diabetes mellitus (T1DM) is a chronic illness characterized by the body’s inability to produce insulin due to the autoimmune destruction of the beta cells in the pancreas. Visfatin is a ubiquitous intracellular enzyme, known as nicotine amide phosphoribosyl transferase (NAMPT) and pre-B-cell colony-enhancing factor (PBEF-1).Objective: The aim of this study was to evaluate serum visfatin level in children and adolescent with type 1 diabetes mellitus (T1DM).Patients and methods: The present study was a case-control study observation that was conducted in Pediatric Endocrinology Unit, Pediatric Ward, Zagazig University Hospitals. The study included 46 children; 23 with T1DM and 23 healthy age- and sex- matched children.Results: In this study, we found that serum visfatin level in diabetic group is statistically highly significant lower than healthy group. The mean serum level of visfatin in healthy group was 19.53 ± 10.5 ng/ml, while in T1DM patients was 2.85 ± 2.09 ng/ml. The best cutoff of serum visfatin level in excluding T1DM was ≥ 3.6 ng/ml with area under curve 0.968 with sensitivity 91.3%, specificity 82.6%, positive predictive value 84%, negative predictive value 90.5%, positive likelihood ratio 5.25, negative likelihood ratio 0.11 and accuracy 87% (p < 0.001). The result showed that serum visfatin could be helpful in prediction of T1DM among children and adolescents with an accuracy 87%.Conclusion: Serum visfatin level is lower in T1DM patients compared to healthy control. Visfatin play a role in early prediction and understanding the mechanism of its action in T1DM could lead to new therapeutic targets. |
وصف الملف: | application/pdf |
اللغة: | English |
تدمد: | 1687-2002 2090-7125 |
الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=78975075580c::825b889d42a205378553ef40363fce6eTest https://www.ajol.info/index.php/ejhm/article/view/223576Test |
رقم الانضمام: | edsair.78975075580c..825b889d42a205378553ef40363fce6e |
قاعدة البيانات: | OpenAIRE |
تدمد: | 16872002 20907125 |
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