دورية
Alterations in adolescent brain serotonin (5HT)1A, 5HT2A, and dopamine (D)2receptor systems in a nonhuman primate model of early life adversity
| العنوان: | Alterations in adolescent brain serotonin (5HT)1A, 5HT2A, and dopamine (D)2receptor systems in a nonhuman primate model of early life adversity |
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| المؤلفون: | Wakeford, Alison G. P., Nye, Jonathon A., Morin, Elyse L., Mun, Jiyoung, Meyer, Jerrold S., Goodman, Mark, Howell, Leonard L., Sanchez, Mar M. |
| المصدر: | Neuropsychopharmacology; 20240101, Issue: Preprints p1-9, 9p |
| مستخلص: | Stress affects brain serotonin (5HT) and dopamine (DA) function, and the effectiveness of 5HT and DA to regulate stress and emotional responses. However, our understanding of the long-term impact of early life adversity (ELA) on primate brain monoaminergic systems during adolescence is scarce and inconsistent. Filling this gap in the literature is critical, given that the emergence of psychopathology during adolescence has been related to deficits in these systems. Here, we use a translational nonhuman primate (NHP) model of ELA (infant maltreatment by the mother) to examine the long-term impact of ELA on adolescent 5HT1A, 5HT2Aand D2receptor systems. These receptor systems were chosen based on their involvement in stress/emotional control, as well as reward and reinforcement. Rates of maternal abuse, rejection, and infant’s vocalizations were obtained during the first three postnatal months, and hair cortisol concentrations obtained at 6 months postnatal were examined as early predictors of binding potential (BP) values obtained during adolescence using positron emission tomography (PET) imaging. Maltreated animals demonstrated significantly lower 5HT1Areceptor BP in prefrontal cortical areas as well as the amygdala and hippocampus, and lower 5HT2Areceptor BP in striatal and prefrontal cortical areas. Maltreated animals also demonstrated significantly lower D2BP in the amygdala. None of the behavioral and neuroendocrine measurements obtained early in life predicted any changes in BP data. Our findings suggest that early caregiving experiences regulate the development of brain 5HT and DA systems in primates, resulting in long-term effects evident during adolescence. |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 0893133X 1740634X |
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| DOI: | 10.1038/s41386-023-01784-0 |