Prognostic impact of cooccurring mutations in FLT3-ITD pediatric acute myeloid leukemia

التفاصيل البيبلوغرافية
العنوان: Prognostic impact of cooccurring mutations in FLT3-ITD pediatric acute myeloid leukemia
المؤلفون: Tarlock, Katherine, Gerbing, Robert B., Ries, Rhonda E., Smith, Jenny L., Leonti, Amanda, Huang, Benjamin J., Kirkey, Danielle, Robinson, Leila, Peplinksi, Jack H., Lange, Beverly, Cooper, Todd M., Gamis, Alan S., Kolb, E. Anders, Aplenc, Richard, Pollard, Jessica A., Alonzo, Todd A., Meshinchi, Soheil
المصدر: Blood Advances; May 2024, Vol. 8 Issue: 9 p2094-2103, 10p
مستخلص: •Cooccurring mutational profile and not allelic ratio determines clinical outcomes for patients with FLT3-ITD.•Therapy intensification improves survival for patients with FLT3-ITD; however, those with cooccurring poor-risk mutations still fare poorly.
قاعدة البيانات: Supplemental Index
الوصف
تدمد:24739529
24739537
DOI:10.1182/bloodadvances.2023011980