Spatial and molecular profiling of the mononuclear phagocyte network in classic Hodgkin lymphoma

التفاصيل البيبلوغرافية
العنوان: Spatial and molecular profiling of the mononuclear phagocyte network in classic Hodgkin lymphoma
المؤلفون: Stewart, Benjamin J., Fergie, Martin, Young, Matthew D., Jones, Claire, Sachdeva, Ashwin, Blain, Alex, Bacon, Chris M., Rand, Vikki, Ferdinand, John R., James, Kylie R., Mahbubani, Krishnaa T., Hook, Liz, Jonas, Nicolaas, Coleman, Nicholas, Saeb-Parsy, Kourosh, Collin, Matthew, Clatworthy, Menna R., Behjati, Sam, Carey, Christopher D.
المصدر: Blood; May 2023, Vol. 141 Issue: 19 p2343-2358, 16p
مستخلص: •Tumor-associated MNP are diverse and spatially polarized: cDC2 colocalize with malignant HRSCs; plasmacytoid and activated DCs are excluded.•DCs, monocytes, and macrophages exist in an inflammatory niche in close proximity to HRSCs, and all express inhibitory molecules.
قاعدة البيانات: Supplemental Index
الوصف
تدمد:00064971
15280020
DOI:10.1182/blood.2022015575