دورية
Pigment Epithelium-Derived Factor (PEDF) Inhibits Multiple Myeloma through Suppressing NADPH Oxidase ROS Generation.
| العنوان: | Pigment Epithelium-Derived Factor (PEDF) Inhibits Multiple Myeloma through Suppressing NADPH Oxidase ROS Generation. |
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| المؤلفون: | Seki, Ritsuko, Yoshida, Takafumi, Nakamura, Kazuo, Yamagishi, Sho-ichi, Imaizumi, Tsutomu, Okamura, Takashi, Sata, Michio |
| المصدر: | Blood; November 2005, Vol. 106 Issue: 11 p3389-3389, 1p |
| مستخلص: | Interaction of multiple myeloma (MM) cells and bone marrow stromal cells (BMSC) plays a crucial role in the pathogenesis of multiple myeloma (MM). IL-6 secreted by BMSCs promotes proliferation and survival of MM cells. IL-6 also enhaces the vascular endothelial growth factor (VEGF) production of MM cells, which in turn promotes secretion of IL-6 from BMSCs. Thus VEGF is both an autocrine growth factor and IL-6 mediated paracrine growth factor of MM cells. VEGF is also angiogenic factor as increasing microvessel density in the BM of MM patients. VEGF stimulates Rac1 dependent NADPH oxidase to produce reactive oxygen species (ROS), which is an important factor for angiogenic response. Pigment epithelium-derived factor (PEDF) is a glycoprotein with M.W. 50,000, belongs to serine protease inhibitor superfamily, and is produced and secred by broad variety of cells. PEDF functions as the most potent inhibtor of angiogenesis in the mammalian eyes. Recently, we reported that PEDF effectively inhibits growth factor-induced ROS generation by suppressing NADPH oxidase. Accordingly, we hypothesized that PEDF would exhibit anti-MM effect by reducing ROS generation. |
| قاعدة البيانات: | Supplemental Index |
Full Text Finder | تدمد: | 00064971 15280020 |
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| DOI: | 10.1182/blood.V106.11.3389.3389 |