دورية
Regulatory myeloid cells paralyze T cells through cell–cell transfer of the metabolite methylglyoxal
| العنوان: | Regulatory myeloid cells paralyze T cells through cell–cell transfer of the metabolite methylglyoxal |
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| المؤلفون: | Baumann, Tobias, Dunkel, Andreas, Schmid, Christian, Schmitt, Sabine, Hiltensperger, Michael, Lohr, Kerstin, Laketa, Vibor, Donakonda, Sainitin, Ahting, Uwe, Lorenz-Depiereux, Bettina, Heil, Jan E., Schredelseker, Johann, Simeoni, Luca, Fecher, Caroline, Körber, Nina, Bauer, Tanja, Hüser, Norbert, Hartmann, Daniel, Laschinger, Melanie, Eyerich, Kilian, Eyerich, Stefanie, Anton, Martina, Streeter, Matthew, Wang, Tina, Schraven, Burkhart, Spiegel, David, Assaad, Farhah, Misgeld, Thomas, Zischka, Hans, Murray, Peter J., Heine, Annkristin, Heikenwälder, Mathias, Korn, Thomas, Dawid, Corinna, Hofmann, Thomas, Knolle, Percy A., Höchst, Bastian |
| المصدر: | Nature Immunology; May 2020, Vol. 21 Issue: 5 p555-566, 12p |
| مستخلص: | Regulatory myeloid immune cells, such as myeloid-derived suppressor cells (MDSCs), populate inflamed or cancerous tissue and block immune cell effector functions. The lack of mechanistic insight into MDSC suppressive activity and a marker for their identification has hampered attempts to overcome T cell inhibition and unleash anti-cancer immunity. Here, we report that human MDSCs were characterized by strongly reduced metabolism and conferred this compromised metabolic state to CD8+T cells, thereby paralyzing their effector functions. We identified accumulation of the dicarbonyl radical methylglyoxal, generated by semicarbazide-sensitive amine oxidase, to cause the metabolic phenotype of MDSCs and MDSC-mediated paralysis of CD8+T cells. In a murine cancer model, neutralization of dicarbonyl activity overcame MDSC-mediated T cell suppression and, together with checkpoint inhibition, improved the efficacy of cancer immune therapy. Our results identify the dicarbonyl methylglyoxal as a marker metabolite for MDSCs that mediates T cell paralysis and can serve as a target to improve cancer immune therapy. |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 15292908 15292916 |
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| DOI: | 10.1038/s41590-020-0666-9 |