دورية
Nelfinavir induces radiation sensitization in pituitary adenoma cells
| العنوان: | Nelfinavir induces radiation sensitization in pituitary adenoma cells |
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| المؤلفون: | Zeng, Jing, See, Alfred P., Aziz, Khaled, Thiyagarajan, Saravanan, Salih, Tarek, Gajula, Rajendra P., Armour, Michael, Phallen, Jillian, Terezakis, Stephanie, Kleinberg, Lawrence, Redmond, Kristen, Hales, Russell K., Salvatori, Roberto, Quinones-Hinojosa, Alfredo, Tran, Phuoc T., Lim, Michael |
| المصدر: | Cancer Biology and Therapy; October 2011, Vol. 12 Issue: 7 p657-663, 7p |
| مستخلص: | Pituitary adenomas with local invasion and high secretory activity remain a therapeutic challenge. The HIV protease inhibitor nelfinavir is a radiosensitizer in multiple tumor models. We tested nelfinavir as a radiosensitizer in pituitary adenoma cells in vitro and in vivo. We examined the effect of nelfinavir with radiation on in vitro cell viability, clonogenic survival, apoptosis, prolactin secretion, cell cycle distribution, and the PI3K-AKT-mTOR pathway. We evaluated tumor growth delay and confirmed nelfinavir's effect on the PI3K-AKT-mTOR pathway in a hind-flank model. Nelfinavir sensitized pituitary adenoma cells to ionizing radiation as shown by viability assays and clonogenic assay with an enhancement ratio of 1.2 (p |
| قاعدة البيانات: | Supplemental Index |
Full Text Finder | تدمد: | 15384047 15558576 |
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| DOI: | 10.4161/cbt.12.7.17172 |