دورية
The real face of endothelial progenitor cells — Circulating angiogenic cells as endothelial prognostic marker?
| العنوان: | The real face of endothelial progenitor cells — Circulating angiogenic cells as endothelial prognostic marker? |
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| المؤلفون: | Kachamakova-Trojanowska, Neli, Bukowska-Strakova, Karolina, Zukowska, Monika, Dulak, Jozef, Jozkowicz, Alicja |
| المصدر: | Pharmacological Reports; July 2015, Vol. 67 Issue: 4 p793-802, 10p |
| مستخلص: | Endothelial progenitor cells (EPCs) have been extensively studied for almost 19 years now and were considered as a potential marker for endothelial regeneration ability. On the other hand, circulating endothelial cells (CEC) were studied as biomarker for endothelial injury. Yet, in the literature, there is also huge incoherency in regards to terminology and protocols used. This results in misleading conclusions on the role of so called “EPCs”, especially in the clinical field. The discrepancies are mainly due to strong phenotypic overlap between EPCs and circulating angiogenic cells (CAC), therefore changes in “EPC” terminology have been suggested. Other factors leading to inconsistent results are varied definitions of the studied populations and the lack of universal data reporting, which could strongly affect data interpretation. The current review is focused on controversies concerning the use of “EPCs”/CAC and CEC as putative endothelial diagnostic markers. |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 17341140 22995684 |
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| DOI: | 10.1016/j.pharep.2015.05.017 |