دورية
Micronutrients in support to the one carbon cycle for the modulation of blood fasting homocysteine in PCOS women
| العنوان: | Micronutrients in support to the one carbon cycle for the modulation of blood fasting homocysteine in PCOS women |
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| المؤلفون: | Schiuma, N., Costantino, A., Bartolotti, T., Dattilo, M., Bini, V., Aglietti, M. C., Renga, M., Favilli, A., Falorni, A., Gerli, S. |
| المصدر: | Journal of Endocrinological Investigation; 20240101, Issue: Preprints p1-8, 8p |
| مستخلص: | Purpose: Fasting blood homocysteine is increased in PCOS women and is involved in several of its co-morbidities including cardiovascular disease and infertility. Corrective interventions based on the administration of supra-physiologic doses of folic acid work to a low extent. We aimed to test an alternative approach. Methods: This was a prospective, randomized, parallel group, open label, controlled versus no treatment clinical study. PCOS women aged > 18, free from systemic diseases and from pharmacological treatments were randomized with a 2:1 ratio for treatment with activated micronutrients in support to the carbon cycle (Impryl, Parthenogen, Switzerland—n= 22) or no treatment (n= 10) and followed-up for 3 months. Fasting blood homocysteine, AMH, testosterone, SHBGs, and the resulting FTI were tested before and at the end of the follow-up. Results: The mean baseline fasting blood homocysteine was above the normal limit of 12 μMol/L and inversely correlated with SHBG. AMH was also increased, whereas testosterone, SHBG, and FTI were within the normal limit. The treatment achieved a significant reduction of homocysteine, that did not change in the control group, independently of the starting value. The treatment also caused an increase of AMH and a decrease of SHBGs only in the subgroup with a normal homocysteine at baseline. Conclusions: In PCOS ladies, blood homocysteine is increased and inversely correlated with the SHBGs. Physiologic amounts of activated micronutrients in support to the carbon cycle achieve a reduction virtually in all exposed patients. Whether this is of clinical benefit remains to be established. |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 03914097 17208386 |
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| DOI: | 10.1007/s40618-019-01163-x |