دورية
MPPimpairs autophagic clearance of alpha-synuclein by impairing the activity of dynein
| العنوان: | MPPimpairs autophagic clearance of alpha-synuclein by impairing the activity of dynein |
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| المؤلفون: | Cai, Zeng-Lin, Shi, Ji-Jun, Yang, Ya-Ping, Cao, Bi-Yin, Wang, Feng, Huang, Jin-Zhong, Yang, Fang, Zhang, Ping, Liu, Chun-Feng |
| المصدر: | NeuroReport; April 2009, Vol. 20 Issue: 6 p569-573, 5p |
| مستخلص: | Increasing evidence suggests that dynein has an important role in the clearance of misfolded proteins by autophagy. Here we show that treatment of cells with 1-methyl-4-phenylpyridinium (MPP) cause -synuclein overexpression and aggregation, leading to the accumulation of autophagic vacuoles and the recruitment of LC3-II to these vacuoles in the cytoplasm. After MPPtreatment, dynein expression decreased and was mainly aggregated at the periphery of cytoplasm and lost its colocalization with -synuclein and lamp1, indicating that dynein lost its function in the aggresome formation and failed to return autophagosome and lysosomes to the center of the cell for degradation. We consider that dynein plays an important role in the autophagic clearance of aggregate-prone proteins. |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 09594965 1473558X |
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| DOI: | 10.1097/WNR.0b013e32832986c4 |