دورية
Insulin delivery and nocturnal glucose control in children and adolescents with type 1 diabetes
| العنوان: | Insulin delivery and nocturnal glucose control in children and adolescents with type 1 diabetes |
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| المؤلفون: | Tauschmann, Martin, Hovorka, Roman |
| المصدر: | Expert Opinion on Drug Delivery; December 2017, Vol. 14 Issue: 12 p1367-1377, 11p |
| مستخلص: | ABSTRACTIntroduction: Nocturnal glucose control remains challenging in children and adolescents with type 1 diabetes due to highly variable overnight insulin requirements. The issue may be addressed by glucose responsive insulin delivery based on real-time continuous glucose measurements.Areas covered: This review outlines recent developments of glucose responsive insulin delivery systems from a paediatric perspective. We cover threshold-based suspend application, predictive low glucose suspend, and more advanced single hormone and dual-hormone closed-loop systems. Approaches are evaluated in relation to nocturnal glucose control particularly during outpatient randomised controlled trials.Expert opinion: Significant progress translating research from controlled clinical centre settings to free-living unsupervised home studies have been achieved over the past decade. Nocturnal glycaemic control can be improved whilst reducing the risk of hypoglycaemia with closed-loop systems. Following the US regulatory approval of the first hybrid closed-loop system in non-paediatric population, large multinational closed-loop clinical trials and pivotal studies including paediatric populations are underway or in preparation to facilitate the use of closed-loop systems in clinical practice. |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 17425247 17447593 |
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| DOI: | 10.1080/17425247.2017.1360866 |