دورية
Co-stimulation modulation with abatacept in patients with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled trial
| العنوان: | Co-stimulation modulation with abatacept in patients with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled trial |
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| المؤلفون: | Orban, Tihamer, Bundy, Brian, Becker, Dorothy J, DiMeglio, Linda A, Gitelman, Stephen E, Goland, Robin, Gottlieb, Peter A, Greenbaum, Carla J, Marks, Jennifer B, Monzavi, Roshanak, Moran, Antoinette, Raskin, Philip, Rodriguez, Henry, Russell, William E, Schatz, Desmond, Wherrett, Diane, Wilson, Darrell M, Krischer, Jeffrey P, Skyler, Jay S |
| المصدر: | The Lancet; July 2011, Vol. 378 Issue: 9789 p412-419, 8p |
| مستخلص: | The immunopathogenesis of type 1 diabetes mellitus is associated with T-cell autoimmunity. To be fully active, immune T cells need a co-stimulatory signal in addition to the main antigen-driven signal. Abatacept modulates co-stimulation and prevents full T-cell activation. We evaluated the effect of abatacept in recent-onset type 1 diabetes. |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 01406736 1474547X |
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| DOI: | 10.1016/S0140-6736(11)60886-6 |