دورية
907-104 Endothelial Injury at a Transiently Occluded Coronary Artery Increases Myocardial Leukocyte Content and Necrosis. Effect of Aspirin
| العنوان: | 907-104 Endothelial Injury at a Transiently Occluded Coronary Artery Increases Myocardial Leukocyte Content and Necrosis. Effect of Aspirin |
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| المؤلفون: | Barrabés, José A., García-Dorado, David, Oliveras, Juan, González, Miguel A., Ruiz-Meana, Marisol, Solares, Julia, García, Amparo, Castell, Joan, Ballester, Ricard, Soler-Soler, J. |
| المصدر: | Journal of the American College of Cardiology; February 1995, Vol. 25 Issue: 2, Number 2 Supplement 1 p58A-58A, 1p |
| مستخلص: | Coronary ligature with minimal intimal injury reproduces only in part acute coronary syndrome, in which reperfusion occurs through an extensively damaged artery. To analyze the influence of coronary endothelial injury (El) on PMN leukocyte accumulation and infarct size, 48 pigs were allocated to catheterization and endothelial denudation of the LAD or to no intervention immediately before a 48min coronary occlusion and 6h of reperfusion. Ninety min before they had received aspirin (ASA, 250mg e.v.), or placebo (2 × 2 factorial design). Twelve animals presented reocclusion and were excluded for subsequent analysis, 2 of them receiving ASA and 10 not (p<0.05). In the remaining pigs, blood flow (ml/[min.g]) in the area at risk was similar in those with than in those without EI. 30min (2.2±0.3 vs 2.3±0.4) and 5h (1.4±0.2 vs 1.4±0.2) after reflow. and was not modified by ASA. Infarct size (% of the area at risk, TIC reaction) was greater in pigs with EI. A significant interaction (p=0.03) between El and ASA was detected, El being associated with larger infarcts in animals receiving placebo, but not in those receiving ASA:No EI (n=18)EI (n=18)p valuePlacebo (n=18)11±436±70.006ASA (n=18)22±620±6NS |
| قاعدة البيانات: | Supplemental Index |
Full Text Finder | تدمد: | 07351097 15583597 |
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| DOI: | 10.1016/0735-1097(95)91696-U |