دورية
Dose-dependency in local disposition of 5-fluorouracil under non-steady-state condition in rat liver
العنوان: | Dose-dependency in local disposition of 5-fluorouracil under non-steady-state condition in rat liver |
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المؤلفون: | Higashimori, Mitsuo, Yamaoka, Kiyoshi, Nakagawa, Terumichi |
المصدر: | Journal of Pharmaceutical Sciences; January 2000, Vol. 89 Issue: 1 p100-107, 8p |
مستخلص: | Dose-dependency in local disposition of 5-fluorouracil (5-FU) was evaluated using the rat liver in the once-through perfusion system under the non-steady-state condition. A curve-fitting program based on Finite Element Method, MULTI(FEM), was adopted to evaluate the capacity-limited elimination in the hepatic local disposition of 5-FU, which is described by a nonlinear dispersion model with a pulse input. The dose of 5-FU was increased from 10.4 to 208 μg for rat livers at five dose levels. Two nonlinear models, two-compartment dispersion models with MichaelisMenten elimination from the central compartment or from the peripheral compartment, were employed for comparison. The hepatic recovery ratio, F |
قاعدة البيانات: | Supplemental Index |
تدمد: | 00223549 15206017 |
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DOI: | 10.1002/(SICI)1520-6017(200001)89:1<100::AID-JPS10>3.0.CO;2-L |