التفاصيل البيبلوغرافية
| العنوان: |
The effect of antiepileptic drugs on thyroid function in children. |
| المؤلفون: |
Yılmaz, Ünsal, Yılmaz, Tuba Sevim, Akıncı, Gülçin, Korkmaz, Hüseyin Anıl, Tekgül, Hasan |
| المصدر: |
Seizure; Jan2014, Vol. 23 Issue 1, p29-35, 7p |
| مستخلص: |
Abstract: Background: Limited and conflicting data exist for the influence of antiepileptic drugs on thyroid function in children. Objective: The aim of this study was to investigate the effects of phenobarbital, valproate, carbamazepine, oxcarbazepine, and levetiracetam monotherapy on thyroid function in daily clinical practice during a 12-month treatment period. Method: A total of 223 children (103 females and 120 males) with new onset and controlled epilepsy treated with valproate (n =129), phenobarbital (n =33), carbamazepine (n =36), oxcarbazepine (n =14), levetiracetam (n =11) were enrolled in the study. Serum free thyroxine (fT4) and thyroid-stimulating hormone (TSH) levels were measured before and at first, sixth and twelfth months of therapy. Results: At baseline, average fT4 and TSH concentrations were not different between the drug groups. Valproate-treated patients had decreased fT4 and increased TSH levels at months 1, 6, and 12. Carbamazepine-treated patients had decreased fT4 levels at months 1, 6, and 12 and increased TSH levels at months 1, and 6. Phenobarbital-treated patients had decreased fT4 levels at months 1, and 6, and increased TSH levels at months 6 and 12. Oxcarbazepine-treated patients had decreased fT4 levels at month 1. Levetiracetam-treated patients showed no significant change of fT4 and TSH at any times. The frequency of subclinical hypothyroidism at month 12 was 28% in valproate, 21.4% in oxcarbazepine, 18.2% in phenobarbital, 13.9% in carbamazepine, and 0% in levetiracetam groups. Conclusion: Our data suggest that all antiepileptic drugs studied except levetiracetam had varying degrees of deleterious effects on thyroid function. [Copyright &y& Elsevier] |
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