التفاصيل البيبلوغرافية
| العنوان: |
Sensitization of pancreatic cancer cells to radiation by cerium oxide nanoparticle-induced ROS production. |
| المؤلفون: |
Wason, Melissa S., Colon, Jimmie, Das, Soumen, Seal, Sudipta, Turkson, James, Zhao, Jihe, Baker, Cheryl H. |
| المصدر: |
Nanomedicine: Nanotechnology, Biology & Medicine; May2013, Vol. 9 Issue 4, p558-569, 12p |
| مصطلحات موضوعية: |
PANCREATIC cancer treatment, CANCER cells, NANOMEDICINE, CANCER radiotherapy, CERIUM oxides, OXYGEN in the body, ADVERSE health care events |
| مستخلص: |
Abstract: Side effect of radiation therapy (RT) remains the most challenging issue for pancreatic cancer treatment. In this report we determined whether and how cerium oxide nanoparticles (CONPs) sensitize pancreatic cancer cells to RT. CONP pretreatment enhanced radiation-induced reactive oxygen species (ROS) production preferentially in acidic cell-free solutions as well as acidic human pancreatic cancer cells. In acidic environments, CONPs favor the scavenging of superoxide radical over the hydroxyl peroxide resulting in accumulation of the latter whereas in neutral pH CONPs scavenge both. CONP treatment prior to RT markedly potentiated the cancer cell apoptosis both in culture and in tumors and the inhibition of the pancreatic tumor growth without harming the normal tissues or host mice. Taken together, these results identify CONPs as a potentially novel RT-sensitizer as well as protectant for improving pancreatic cancer treatment. From the Clinical Editor: Pancreatic tumors remain some of the most notoriously treatment-unresponsive malignancies. Cerium oxide nanoparticles may be capable of sensitizing such cells to radiotherapy, as demonstrated in this study. [Copyright &y& Elsevier] |
|
Copyright of Nanomedicine: Nanotechnology, Biology & Medicine is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Supplemental Index |
