التفاصيل البيبلوغرافية
| العنوان: |
Comparison of patterns of relapse in thymic carcinoma and thymoma. |
| المؤلفون: |
Huang, James, Rizk, Nabil P., Travis, William D., Riely, Gregory J., Park, Bernard J., Bains, Manjit S., Dycoco, Joseph, Flores, Raja M., Downey, Robert J., Rusch, Valerie W. |
| المصدر: |
Journal of Thoracic & Cardiovascular Surgery; Jul2009, Vol. 138 Issue 1, p26-31, 6p |
| مصطلحات موضوعية: |
THYMUS tumors, CANCER relapse, COMPARATIVE method, TUMOR prognosis, HEALTH outcome assessment, COHORT analysis, POSITRON emission tomography |
| مصطلحات جغرافية: |
UNITED States |
| الشركة/الكيان: |
WORLD Health Organization |
| مستخلص: |
Objective: Thymic carcinomas are considered to be more aggressive than thymomas and carry a worse prognosis. We reviewed our recent experience with the surgical management of thymic tumors and compared the outcomes and patterns of relapse between patients with thymic carcinoma and those with thymoma. Methods: We performed a single-institution retrospective cohort study. Data included patient demographics, stage, treatment, pathologic findings, and postoperative outcomes. Results: During the period 1995–2006, 120 patients with thymic tumors underwent surgical intervention, including 23 patients with thymic carcinoma and 97 patients with thymoma, as classified according to the World Health Organization 2004 histologic classification. The overall 5-year survival was significantly different between patients with thymic carcinoma and those with thymoma (thymic carcinoma, 53%; thymoma, 89%; P = .01). Data on relapse were available for 112 patients. The progression-free 5-year survival was also significantly different between patients with thymic carcinoma and those with thymoma (thymic carcinoma, 36%; thymoma, 75%; P < .01). Using multivariate analysis, thymic carcinoma and incomplete resection were found to be independent predictors of progression-free survival. Relapses in patients with thymic carcinoma tended to occur earlier, and occurred significantly more frequently at distant sites than in patients with thymoma (60% vs 13%, P = .01). Conclusions: Patterns of relapse differ significantly between patients with thymic carcinoma and those with thymoma, with lower progression-free survival, earlier onset, and more distant relapses in patients with thymic carcinoma. Given the greater propensity for distant failures, the inclusion of systemic therapy in the treatment of thymic carcinoma might take on greater importance. Despite significantly higher rates of distant relapse, good overall survival in patients with thymic carcinoma can be achieved. [Copyright &y& Elsevier] |
|
Copyright of Journal of Thoracic & Cardiovascular Surgery is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Supplemental Index |
Full Text Finder