التفاصيل البيبلوغرافية
| العنوان: |
Association between FOXP2 polymorphisms and schizophrenia with auditory hallucinations. |
| المؤلفون: |
Julio Sanjuán |
| المصدر: |
Psychiatric Genetics; Apr2006, Vol. 16 Issue 2, p67-72, 6p |
| مصطلحات موضوعية: |
LANGUAGE disorders, SCHIZOPHRENIA, GENETIC polymorphisms, AUDITORY hallucinations |
| مستخلص: |
OBJECTIVE: A mutation in the FOXP2 gene has been the first genetic association with a language disorder. Language disorder is considered as a core symptom of schizophrenia. Therefore, the FOXP2 gene could be considered a good candidate gene for the vulnerability to schizophrenia.METHODS: A set of single nucleotide polymorphisms mainly located in the 5′ regulatory region of the FOXP2 gene was analysed in a sample of 186 DSM-IV schizophrenic patients with auditory hallucinations and in 160 healthy controls.RESULTS: Statistically significant differences in the genotype (P=0.007) and allele frequencies (P=0.0027) between schizophrenic patients with auditory hallucinations and controls were found in the single nucleotide polymorphism rs2396753. These P values changed to 0.07 and 0.0273, respectively, after Bonferroni sequential correction. The haplotype rs7803667T/rs10447760C/rs923875A/rs1358278A/rs2396753A (TCAAA) also showed a significant difference confirmed with a permutation test (P=0.009).CONCLUSIONS: These results suggested that the FOXP2 gene may confer vulnerability to schizophrenic patients with auditory hallucinations. [ABSTRACT FROM AUTHOR] |
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