التفاصيل البيبلوغرافية
| العنوان: |
Neutrophil-only Histological Assessment of Ulcerative Colitis Correlates with Endoscopic Activity and Predicts Long-term Outcomes in a Multicentre Study. |
| المؤلفون: |
Parigi, Tommaso L, Cannatelli, Rosanna, Nardone, Olga M, Zammarchi, Irene, Shivaji, Uday, Furfaro, Federica, Zardo, Davide, Spaggiari, Paola, Sordo, Rachele Del, Setti, Orsola, Majumder, Snehali, Smith, Samuel C L, Danese, Silvio, Armuzzi, Alessandro, Villanacci, Vincenzo, Ghosh, Subrata, Iacucci, Marietta |
| المصدر: |
Journal of Crohn's & Colitis; Dec2023, Vol. 17 Issue 12, p1931-1938, 8p |
| مستخلص: |
Backgrounds and Aims Absence of neutrophils is the minimum standard to consider histological remission of ulcerative colitis [UC]. The PICaSSO Histological Remission Index [PHRI] is a new simple index for UC, based only on the detection of neutrophils. We evaluate PHRI's correlation with endoscopy and its prognostic value compared with other established indices. Methods Consecutive patients with UC underwent colonoscopy at two referral centres [Birmingham, UK, and Milan, Italy,] and were followed up for 2 years. Correlation between histology (PHRI, Nancy [NHI], and Robarts [RHI] indexes) and endoscopy (Mayo Endoscopic Score [MES], Ulcerative Colitis Endoscopic Index of Severity [UCEIS], and PICaSSO index) was calculated as Spearman coefficients. Diagnostic performance of endoscopy was assessed with receiver operating characteristic [ROC] curves and outcome stratification with Kaplan–Meier curves. Results A total of 192 patients with UC was enrolled, representing all grades of endoscopic severity. Correlation between histology and endoscopy did not differ significantly when using PHRI instead of NHI or RHI. In particular, PHRI's correlation with MES, UCEIS, and PICaSSO was 0.745, 0.718, and 0.694, respectively. Endoscopically-assessed remission reflected the absence of neutrophils [PHRI = 0] with areas under the ROC curve of 0.905, 0.906, and 0.877 for MES, UCEIS, and PICaSSO, respectively. The hazard ratio for disease flare between patients in histological activity/remission was statistically similar [p >0.05] across indexes [2.752, 2.706, and 2.871 for RHI, NHI, and PHRI, respectively]. Conclusion PHRI correlates with endoscopy and stratifies risk of relapse similarly to RHI and NHI. Neutrophil-only assessment of UC is a simple yet viable alternative to established histological scores. [ABSTRACT FROM AUTHOR] |
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