التفاصيل البيبلوغرافية
| العنوان: |
The effect of polystyrene nanoplastics on arsenic-induced apoptosis in HepG2 cells. |
| المؤلفون: |
He, Lei, Lu, Zifan, Zhang, Yuanyuan, Yan, Linhong, Ma, Lihua, Dong, Xiaoling, Wu, Zijie, Dai, Zhenqing, Tan, Baoyi, Sun, Ruikun, Sun, Shengli, Li, Chengyong |
| المصدر: |
Ecotoxicology & Environmental Safety; Jan2024, Vol. 269, pN.PAG-N.PAG, 1p |
| مصطلحات موضوعية: |
POLYSTYRENE, MICROPLASTICS, ARSENIC poisoning, LACTATE dehydrogenase, MEMBRANE potential, BIODEGRADABLE plastics |
| مستخلص: |
Microplastics are detrimental to the environment. However, the combined effects of microplastics and arsenic (As) remain unclear. In this study, we investigated the combined effects of polystyrene (PS) microplastics and As on HepG2 cells. The results showed that PS microplastics 20, 50, 200, and 500 nm in size were taken up by HepG2 cells, causing a decrease in cellular mitochondrial membrane potential. The results of lactate dehydrogenase release and flow cytometry showed that PS microplastics, especially those of 50 nm, enhanced As-induced apoptosis. In addition, transcriptome analysis revealed that TP53, AKT1, CASP3, ACTB, BCL2L1, CASP8, XIAP, MCL1, NFKBIA, and CASP7 were the top 10 hub genes for PS that enhanced the role of As in HepG2 cell apoptosis. Our results suggest that nano-PS enhances As-induced apoptosis. Furthermore, this study is important for a better understanding of the role of microplastics in As-induced hepatotoxicity. [Display omitted] • Polystyrene microplastics exacerbated arsenic-induced hepatocytotoxicity. • Nano polystyrene microplastics had the greatest impact on arsenic toxicity. • The TP53 gene plays an important regulatory role in the enhanced hepatotoxicity of arsenic by Polystyrene microplastics. [ABSTRACT FROM AUTHOR] |
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