التفاصيل البيبلوغرافية
| العنوان: |
Co-infection of COVID-19 patients with atypical bacteria: A study based in Jordan. |
| المؤلفون: |
Alsayed, Ahmad R., Hasoun, Luai, Khader, Heba A., Abu-Samak, Mahmoud S., Al-Shdifat, Laith M. H., Al-shammari, Basheer, Al Maqbali, Mohammed |
| المصدر: |
Pharmacy Practice (1886-3655); Jan-Mar2023, Vol. 21 Issue 1, p1-5, 5p |
| مصطلحات موضوعية: |
BACTERIAL protein analysis, NASOPHARYNX microbiology, MYCOPLASMA, COVID-19, CHLAMYDOPHILA infections, MYCOPLASMA pneumoniae infections, RETROSPECTIVE studies, MIXED infections, DESCRIPTIVE statistics, DISEASE prevalence, POLYMERASE chain reaction, STATISTICAL correlation, CHLAMYDOPHILA pneumoniae |
| مصطلحات جغرافية: |
JORDAN |
| مستخلص: |
Objective: The aim of this work was to know the prevalence of Chlamydophila pneumoniae and Mycoplasma pneumoniae in coronavirus disease 2019 (COVID-19) patients in Jordan. Also, to assess a TaqMan real-time polymerase chain reaction (PCR) assay in detecting these two bacteria. Methods: This is a retrospective study performed over the last five months of the 2021. All nasopharyngeal specimens from COVID-19 patients were tested for C. pneumonia, and M. pneumoniae. The C. pneumoniae Pst-1 gene and M. pneumoniae P1 cytadhesin protein gene were the targets. Results: In this study, 14 out of 175 individuals with confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (8.0%) were co-infected with C. pneumoniae or M. pneumoniae. Co-infection with SARS-CoV-2 and C. pneumoniae was reported in 5 (2.9%) patients, while 9 (5.1%) patients had M. pneumoniae and SARS-CoV-2 co-infection. The mean (± std) of the correlation coefficient of the calibration curve for real-time PCR analysis was -0.993 (± 0.001) for C. pneumoniae and -0.994 (± 0.003) for M. pneumoniae. The mean amplification efficiencies of C. pneumoniae and M. Pneumoniae were 187.62% and 136.86%, respectively. Conclusion: In this first study based in Jordan, patients infected with COVID-19 have a low rate of atypical bacterial co-infection. However, clinicians should suspect co-infections with both common and uncommon bacteria in COVID-19 patients. Large prospective investigations are needed to give additional insight on the true prevalence of these co-infections and their impact on the clinical course of COVID-19 patients. [ABSTRACT FROM AUTHOR] |
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