التفاصيل البيبلوغرافية
| العنوان: |
Therapeutic Response to Single-Inhaler Triple Therapies in Moderate-to-Severe COPD. |
| المؤلفون: |
Kengo Ohtsuka, Naoko Harada, Atsuo Horiuchi, Shintaro Umemoto, Ryo Kurabatashi, Akie Yui, Hiroyuki Yamamura, Yoko Shinka, Naoki Miyao |
| المصدر: |
Respiratory Care; Mar2023, Vol. 68 Issue 3, p330-337, 8p |
| مصطلحات موضوعية: |
ADRENERGIC beta agonists, STATISTICS, COMBINATION drug therapy, CONFIDENCE intervals, ANALYSIS of variance, CONTINUING education units, MANN Whitney U Test, SEVERITY of illness index, TREATMENT effectiveness, COMPARATIVE studies, T-test (Statistics), OBSTRUCTIVE lung diseases, PULMONARY function tests, DESCRIPTIVE statistics, INHALATION administration, ODDS ratio, DATA analysis, DATA analysis software, SENSITIVITY & specificity (Statistics), MUSCARINIC antagonists, BECLOMETHASONE dipropionate |
| مصطلحات جغرافية: |
JAPAN |
| مستخلص: |
BACKGROUND: COPD is characterized by progressive and irreversible air flow limitations. Single-inhaler therapies (SITTs) incorporating an inhaled corticosteroid, a long-acting muscarinic antagonist, and a long-acting β2-agonist have been shown to effectively alleviate symptoms and improve lung function. Fluticasone-furoate/umeclidinium/vilanterol (F/U/V) and budesonide/glyco-pyrronium/formoterol (B/G/F) are available as SITT in Japan. However, the clinical differences between these 2 combinations and the predictors of their proper use have not been established. This study aimed to identify the subject characteristics that could predict the effectiveness of inhaler therapy. METHODS: We assessed the pulmonary function test results of subjects with COPD before and one month after using F/U/V and B/G/F as SITT. Subjects with a difference of 100 mL or more in the FEV1 after treatment with pre-SITT were extracted and divided into the F/U/V effect and no-effect group and B/G/F effect and no-effect group to examine the factors associated with positive outcomes with each inhaler. RESULTS: F/U/V and B/G/F significantly improved the inspiratory capacity (IC), %IC, FVC, and %FEV1 when compared to pre-inter-vention values (P < .001, P = .001, P = .007, P = .009, respectively, for F/U/V; and P = .006, P = .008, P = .038, P = .005, respectively, for B/G/F). Factors associated with FEV1 improvement in F/U/V included lower %IC (odds ratio 0.97 [95% CI 0.94-0.99], P = .03) and a higher modified Medical Research Council (mMRC) dyspnea score (2.36 [1.27-4.70], P < .01). In addition, a higher %IC (1.03 [1.00-1.06], P = .02) and lower mMRC dyspnea score (0.55 [0.28-0.99], P = .041) were predictors for the effectiveness of B/G/F. CONCLUSIONS: Our results showed that SITT significantly improved the IC, %IC, FVC, and %FEV1 when compared to pre-inter-vention and that F/U/V was more effective in subjects with severe symptoms, whereas B/G/F was more effective in subjects with mild symptoms. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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