التفاصيل البيبلوغرافية
| العنوان: |
Predicting the Need for Step-Up Therapy After EUS-Guided Drainage of Pancreatic Fluid Collections With Lumen-Apposing Metal Stents. |
| المؤلفون: |
Chandrasekhara, Vinay, Elhanafi, Sherif, Storm, Andrew C., Takahashi, Naoki, Lee, Nam Ju, Levy, Michael J., Kaura, Karan, Wang, Lillian, Majumder, Shounak, Vege, Santhi S., Law, Ryan J., Abu Dayyeh, Barham K. |
| المصدر: |
Clinical Gastroenterology & Hepatology; Oct2021, Vol. 19 Issue 10, p2192-2198, 7p |
| مستخلص: |
A significant proportion of individuals with pancreatic fluid collections (PFCs) require step-up therapy after endoscopic drainage with lumen-apposing metal stents. The aim of this study is to identify factors associated with PFCs that require step-up therapy. A retrospective cohort study of patients undergoing endoscopic ultrasound–guided drainage of PFCs with lumen-apposing metal stents from April 2014 to October 2019 at a single center was performed. Step-up therapy included direct endoscopic necrosectomy, additional drainage site (endoscopic or percutaneous), or surgical intervention after the initial drainage procedure. Multivariable logistic regression was performed using a backward stepwise approach with a P ≤.2 threshold for variable retention to identify factors predictive for the need for step-up therapy. One hundred thirty-six patients were included in the final study cohort, of whom 69 (50.7%) required step-up therapy. Independent predictors of step-up therapy included: collection size measuring ≥10 cm (odds ratio [OR], 8.91; 95% confidence interval [CI], 3.36–23.61), paracolic extension of the PFC (OR, 4.04; 95% CI, 1.60–10.23), and ≥30% solid necrosis (OR, 4.24; 95% CI, 1.48–12.16). In a sensitivity analysis of 81 patients with walled-off necrosis, 51 (63.0%) required step-up therapy. Similarly, factors predictive of the need for step-up therapy for walled-off necrosis included: collection size measuring ≥10 cm (OR, 6.94; 95% CI, 1.76–27.45), paracolic extension of the PFC (OR, 3.79; 95% CI, 1.18–12.14), and ≥30% solid necrosis (OR, 7.10; 95% CI, 1.16–43.48). Half of all patients with PFCs drained with lumen-apposing metal stents required step-up therapy, most commonly direct endoscopic necrosectomy. Individuals with PFCs ≥10 cm in size, paracolic extension, or ≥30% solid necrosis are more likely to require step-up therapy and should be considered for early endoscopic reintervention. [ABSTRACT FROM AUTHOR] |
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