التفاصيل البيبلوغرافية
| العنوان: |
Cytokine-specific autoantibodies shape the gut microbiome in autoimmune polyendocrine syndrome type 1. |
| المؤلفون: |
Petersen, Anders Ø., Jokinen, Martta, Plichta, Damian R., Liebisch, Gerhard, Gronwald, Wolfram, Dettmer, Katja, Oefner, Peter J., Vlamakis, Hera, Chung, Daniel C., Ranki, Annamari, Xavier, Ramnik J. |
| المصدر: |
Journal of Allergy & Clinical Immunology; Sep2021, Vol. 148 Issue 3, p876-888, 13p |
| مستخلص: |
Gastrointestinal dysfunction is a frequent and disabling manifestation of autoimmune polyendocrine syndrome type 1 (APS-1), a rare monogenic multiorgan autoimmune disease caused by the loss of central AIRE-controlled immune tolerance. This study aimed to understand the role of the gut microbiome in APS-1 symptoms and potentially alleviate common gastrointestinal symptoms by probiotic intervention. This study characterized the fecal microbiomes of 28 patients with APS-1 and searched for associations with gastrointestinal symptoms, circulating anti-cytokine autoantibodies, and tryptophan-related metabolites. Additionally, daily doses of the probiotic Lactobacillus rhamnosus GG were administered for 3 months. Of 581 metagenomic operational taxonomic units (mOTUs) characterized in total, 14 were significantly associated with patients with APS-1 compared with healthy controls, with 6 mOTUs depleted and 8 enriched in patients with APS-1. Four overabundant mOTUs were significantly associated with severity of constipation. Phylogenetically conserved microbial associations with autoantibodies against cytokines were observed. After the 3-month intervention with the probiotic L rhamnosus GG, a subset of gastrointestinal symptoms were alleviated. L rhamnosus GG abundance was increased postintervention and corresponded with decreased abundances of Alistipes onderdonkii and Collinsella aerofaciens, 2 species positively associated with severity of diarrhea in patients with APS-1. The APS-1 microbiome correlates with several APS-1 symptoms, some of which are alleviated after a 3-month L rhamnosus GG intervention. Autoantibodies against cytokines appear to shape the gut microbiome by positively correlating with a taxonomically consistent group of bacteria. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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