التفاصيل البيبلوغرافية
| العنوان: |
Cytokine Levels at Birth in Children Who Developed Acute Lymphoblastic Leukemia. |
| المؤلفون: |
Whitehead, Todd P., Wiemels, Joseph L., Mi Zhou, Kang, Alice Y., McCoy, Lucie S., Rong Wang, Fitch, Briana, Petrick, Lauren M., Yukiko Yano, Imani, Partow, Rappaport, Stephen M., Dahl, Gary V., Kogan, Scott C., Xiaomei Ma, Metayer, Catherine |
| المصدر: |
Cancer Epidemiology, Biomarkers & Prevention; Aug2021, Vol. 30 Issue 8, p1526-1535, 10p |
| مستخلص: |
Background: Prenatal immune development may play an important role in the etiology of childhood acute lymphoblastic leukemia (ALL). Methods: Seven cytokines, IL1β, IL4, IL6, IL8, GM-CSF, TNFα, and VEGF, were analyzed in blood spots collected at birth from 1,020 ALL cases and 1,003 controls participating in the California Childhood Leukemia Study. ORs and 95% confidence intervals (95% CI) associated with an interquartile range increment in cytokine levels were calculated using logistic regression, adjusting for sociodemographic and birth characteristics. Results: We found that patients with ALL were born with higher levels of a group of correlated cytokines than controls [IL1β: OR of 1.18 (95% confidence interval [CI], 1.03-1.35); IL8: 1.19 (1.03-1.38); TNFα: 1.15 (1.01-1.30); VEGF: 1.16 (1.01-1.33)], especially among children of Latina mothers (ORs from 1.31 to 1.40) and for ALL with high hyperdiploidy (ORs as high as 1.27). We found that neonatal cytokine levels were correlated with neonatal levels of endogenous metabolites which had been previously associated with ALL risk; however, there was no evidence that the cytokines were mediating the relationship between these metabolites and ALL risk. Conclusions: We posit that children born with altered cytokine levels are set on a trajectory towards an increased risk for subsequent aberrant immune reactions that can initiate ALL. [ABSTRACT FROM AUTHOR] |
|
Copyright of Cancer Epidemiology, Biomarkers & Prevention is the property of American Association for Cancer Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Supplemental Index |
Full Text Finder