التفاصيل البيبلوغرافية
| العنوان: |
A comparison of mortality-related risk factors of COVID-19, SARS, and MERS: A systematic review and meta-analysis. |
| المؤلفون: |
Lu, Lvliang, Zhong, Wenyu, Bian, Ziwei, Li, Zhiming, Zhang, Ke, Liang, Boxuan, Zhong, Yizhou, Hu, Manjiang, Lin, Li, Liu, Jun, Lin, Xi, Huang, Yuji, Jiang, Junying, Yang, Xingfen, Zhang, Xin, Huang, Zhenlie |
| المصدر: |
Journal of Infection; Oct2020, Vol. 81 Issue 4, pe18-e25, 8p |
| مصطلحات موضوعية: |
SARS epidemiology, VIRAL pneumonia, C-reactive protein, HYPERTENSION, META-analysis, LUNG diseases, SYSTEMATIC reviews, COVID-19, DIABETES, NEUTROPHILS, SEX distribution, LACTATE dehydrogenase, EPIDEMICS, SARS virus, SARS disease, MERS coronavirus |
| مستخلص: |
Objective: Coronavirus Disease 2019 (COVID-19) is a pandemic. This systematic review compares mortality risk factors including clinical, demographic and laboratory features of COVID-19, Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS). The aim is to provide new strategies for COVID-19 prevention and treatment.Methods: We performed a systematic review with meta-analysis, using five databases to compare the predictors of death for COVID-19, SARS and MERS. A random-effects model meta-analysis calculated odds ratios (OR) and 95% confidence intervals (95% CI).Results: 845 articles up through 11/4/2020 were retrieved, but only 28 studies were included in this meta-analysis. The results showed that males had a higher likelihood of death than females (OR = 1.82, 95% CI 1.56-2.13). Age (OR = 7.86, 95% CI 5.46-11.29), diabetes comorbidity (OR = 3.73, 95% CI 2.35-5.90), chronic lung disease (OR = 3.43, 95% CI 1.80-6.52) and hypertension (OR = 3.38, 95% CI 2.45-4.67) were the mortality risk factors. The laboratory indicators lactic dehydrogenase (OR = 37.52, 95% CI 24.68-57.03), C-reactive protein (OR = 12.11, 95% CI 5.24-27.98), and neutrophils (OR = 17.56, 95% CI 10.67-28.90) had stronger correlations with COVID-19 mortality than with SARS or MERS mortality. Consolidation and ground-glass opacity imaging features were similar among COVID-19, SARS, and MERS patients.Conclusions: COVID-19's mortality factors are similar to those of SARS and MERS. Age and laboratory indicators could be effective predictors of COVID-19 mortality outcomes. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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