التفاصيل البيبلوغرافية
| العنوان: |
Hemodynamic correlates of right ventricular dilation in pulmonary hypertension due to HFpEF. |
| المؤلفون: |
Berthelot, E., Bailly, M.T., Elhatimi, S., Robard, I., Montani, D., Sitbon, O., Chemla, D., Assayag, P. |
| المصدر: |
Archives of Cardiovascular Diseases Supplements; Jan2018, Vol. 10 Issue 1, p30-31, 2p |
| مستخلص: |
Background Right ventricular (RV) remodelling and pulmonary hypertension (PH) are increasingly recognized in heart failure with preserved ejection fraction (HFpEF), with high prevalence and poor outcome. Factors leading to RV dilation in PH-HFpEF patients are unknown. Purpose We thought to determine the hemodynamic correlates of RV dilation in HFpEF patients with PH. Methods We analysed hemodynamic, echocardiographic and clinical characteristics of 93 PH-HFpEF patients (60 women) enrolled prospectively in our center. PH-HFpEF was defined by a resting mean pulmonary artery pressure (mPAP) ≥ 25 mmHg and pulmonary artery wedge pressure (PAWP) > 15 mmHg RV dilation was defined as end diastolic right ventricular area (EDRVA) > 20 cm 2 at echocardiography. Results Mean age (± SD) was 69 ± 12 years, mPAP was 40 ± 10 mmHg, PAWP was 21 ± 4 mmHg. 30 PH-HFpEF patients (31%) had RV dilation. The Pearson correlation coefficients between indexed EDRVA and hemonynamic parameters were 0.39 for right atrial pressure (RAP) and 0.36 for diastolic gradient (each P < 0.001) and 0.20 for effective arterial elastance Ea ( P = 0.049). There was no correlation between EDRVA and PAWP, pulmonary vascular resistance, pulmonary arterial compliance or pulmonary arterial stiffness. Conclusion In PH-HFpEF patients, we documented a significant relationship between RV remodeling and both RAP and the diastolic pressure gradient. Amongst the classic parameters quantifying pulmonary arterial, only Ea weakly contributed. [ABSTRACT FROM AUTHOR] |
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