التفاصيل البيبلوغرافية
| العنوان: |
Asymmetric Hydrogenation of Pyridinium Salts with an Iridium Phosphole Catalyst. |
| المؤلفون: |
Chang, Mingxin, Huang, Yuhua, Liu, Shaodong, Chen, Yonggang, Krska, Shane W., Davies, Ian W., Zhang, Xumu |
| المصدر: |
Angewandte Chemie; Nov2014, Vol. 126 Issue 47, p12975-12978, 4p |
| مصطلحات موضوعية: |
PYRIDINIUM compounds, HYDROGENATION, ASYMMETRIC synthesis, PHOSPHOLES, IRIDIUM catalysts, ENANTIOSELECTIVE catalysis |
| مستخلص: |
Iridium-catalyzed asymmetric hydrogenation of N-alkyl-2-alkylpyridinium salts provided 2-aryl-substituted piperidines with high levels of enantioselectivity. Simple benzyl and other alkyl groups successfully activated the challenging pyridine substrates toward hydrogenation. The use of the unusual chiral-phosphole-based MP2-SEGPHOS was the key to the success of this approach which provides a versatile and practical procedure for the synthesis of chiral piperidines. [ABSTRACT FROM AUTHOR] |
|
Copyright of Angewandte Chemie is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
