التفاصيل البيبلوغرافية
| العنوان: |
In Silico Sequence Analysis Reveals New Characteristics of Fungal NADPH Oxidase Genes. |
| المؤلفون: |
Détry, Nicolas, Jaeyoung Choi, Hsiao-Che Kuo, Asiegbu, Fred O., Yong-Hwan Lee |
| المصدر: |
Mycobiology; Sep2014, Vol. 42 Issue 3, p241-248, 8p |
| مصطلحات موضوعية: |
NADPH oxidase, FUNGAL genomes, PHYLOGENY, GLYCOSYLATION, HISTIDINE |
| مستخلص: |
NADPH oxidases (Noxes), transmembrane proteins found in most eukaryotic species, generate reactive oxygen species and are thereby involved in essential biological processes. However, the fact that genes encoding ferric reductases and ferricchelate reductases share high sequence similarities and domains with Nox genes represents a challenge for bioinformatic approaches used to identify Nox-encoding genes. Further, most studies on fungal Nox genes have focused mainly on functionality, rather than sequence properties, and consequently clear differentiation among the various Nox isoforms has not been achieved. We conducted an extensive sequence analysis to identify putative Nox genes among 34 eukaryotes, including 28 fungal genomes and one Oomycota genome. Analyses were performed with respect to phylogeny, transmembrane helices, di-histidine distance and glycosylation. Our analyses indicate that the sequence properties of fungal Nox genes are different from those of human and plant Nox genes, thus providing novel insight that will enable more accurate identification and characterization of fungal Nox genes. [ABSTRACT FROM AUTHOR] |
|
Copyright of Mycobiology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder