التفاصيل البيبلوغرافية
| العنوان: |
The diagnostic, predictive, and prognostic role of serum epithelial cell adhesion molecule (EpCAM) and vascular cell adhesion molecule-1 (VCAM-1) levels in breast cancer. |
| المؤلفون: |
Karabulut, S., Tas, F., Tastekin, D., Karabulut, M., Yasasever, C., Ciftci, R., Güveli, M., Fayda, M., Vatansever, S., Serilmez, M., Disci, R., Aydıner, A. |
| المصدر: |
Tumor Biology (Springer Science & Business Media B.V.); Sep2014, Vol. 35 Issue 9, p8849-8860, 12p |
| مستخلص: |
The purpose of this study was to determine the clinical significance of vascular cell adhesion molecule-1 (VCAM-1) and epithelial cell adhesion molecule (EpCAM) in breast cancer (BC) patients. Ninety-six BC patients and 30 age- and sex-matched healthy controls were enrolled into this study. Pretreatment serum markers were determined by the solid-phase sandwich (enzyme-linked immunosorbent assay (ELISA)). The median age at diagnosis was 48 years (range 29-80 years). Majority of the patients (71 %) had luminal subtype, and 38.5 % had metastatic disease. Twenty-nine (30 %) patients showed tumor progression, and 20 (21 %) patients died during follow-up. Median progression-free survival (PFS) and overall survival (OS) were 8.6 ± 1.7 and 35.5 ± 1.5 months, respectively. The baseline serum EpCAM levels of the patients were significantly higher than those of the controls ( p < 0.001). There was no significant difference in the serum levels of VCAM-1 between the patients and controls ( p = 0.47). No significant correlation was detected between the levels of the serum markers and other clinical parameters ( p > 0.05). Patients with HER-2-positive and triple-negative tumors had significantly poorer PFS ( p = 0.04 and p = 0.001, respectively), while metastatic disease and chemotherapy unresponsiveness had significantly adverse effect on OS analysis ( p < 0.001 and p < 0.001, respectively). Neither serum VCAM-1 levels nor serum EpCAM levels were identified to have a prognostic role on either PFS or OS (VCAM-1 p = 0.76 and p = 0.32; EpCAM p = 0.16 and p = 0.69, respectively). Even though any predictive or prognostic role could not be determined for both markers, serum levels of EpCAM were found to have diagnostic value in BC patients. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
