التفاصيل البيبلوغرافية
| العنوان: |
Alcohol consumption and cognitive performance: a Mendelian randomization study. |
| المؤلفون: |
Kumari, Meena, Holmes, Michael V., Dale, Caroline E., Hubacek, Jaroslav A., Palmer, Tom M., Pikhart, Hynek, Peasey, Anne, Britton, Annie, Horvat, Pia, Kubinova, Ruzena, Malyutina, Sofia, Pajak, Andrzej, Tamosiunas, Abdonas, Shankar, Aparna, Singh‐Manoux, Archana, Voevoda, Mikhail, Kivimaki, Mika, Hingorani, Aroon D., Marmot, Michael G., Casas, Juan P. |
| المصدر: |
Addiction; Sep2014, Vol. 109 Issue 9, p1462-1471, 10p, 4 Charts, 2 Graphs |
| مصطلحات موضوعية: |
COMPLICATIONS of alcoholism, COGNITION, CONFIDENCE intervals, ALCOHOL drinking, GENETIC polymorphisms, GENETICS, MEMORY, QUESTIONNAIRES, RESEARCH funding, THOUGHT & thinking, PHONOLOGICAL awareness, DATA analysis software, DESCRIPTIVE statistics, ODDS ratio |
| مصطلحات جغرافية: |
EUROPE |
| مستخلص: |
Aims To use Mendelian randomization to assess whether alcohol intake was causally associated with cognitive function. Design Mendelian randomization using a genetic variant related to alcohol intake (ADH1B rs1229984) was used to obtain unbiased estimates of the association between alcohol intake and cognitive performance. Setting Europe. Participants More than 34 000 adults. Measurements Any versus no alcohol intake and units of intake in the previous week was measured by questionnaire. Cognitive function was assessed in terms of immediate and delayed word recall, verbal fluency and processing speed. Findings Having consumed any versus no alcohol was associated with higher scores by 0.17 standard deviations (SD) [95% confidence interval (CI) = 0.15, 0.20] for immediate recall, 0.17 SD (95% CI = 0.14, 0.19) for delayed recall, 0.17 SD (95% CI = 0.14, 0.19) for verbal fluency and 0.12 SD (95% CI = 0.09, 0.15) for processing speed. The minor allele of rs1229984 was associated with reduced odds of consuming any alcohol (odds ratio = 0.87; 95% CI = 0.80, 0.95; P = 0.001; R2 = 0.1%; F-statistic = 47). In Mendelian randomization analysis, the minor allele was not associated with any cognitive test score, and instrumental variable analysis suggested no causal association between alcohol consumption and cognition: −0.74 SD (95% CI = −1.88, 0.41) for immediate recall, −1.09 SD (95% CI = −2.38, 0.21) for delayed recall, −0.63 SD (95% CI = −1.78, 0.53) for verbal fluency and −0.16 SD (95% CI = −1.29, 0.97) for processing speed. Conclusions The Mendelian randomization analysis did not provide strong evidence of a causal association between alcohol consumption and cognitive ability. [ABSTRACT FROM AUTHOR] |
|
Copyright of Addiction is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
