التفاصيل البيبلوغرافية
| العنوان: |
Effect of intraportal glucagon-like peptide-1 on glucose metabolism in conscious dogs. |
| المؤلفون: |
Nishizawa, Makoto, Moore, Mary Courtney, Shiota, Masakazu, Gustavson, Stephanie M., Snead, Wanda L., Neal, Doss W., Cherrington, Alan D. |
| المصدر: |
American Journal of Physiology: Endocrinology & Metabolism; May2003, Vol. 47 Issue 5, pE1027, 10p, 2 Charts, 12 Graphs |
| مصطلحات موضوعية: |
GLUCAGON-like peptide 1, METABOLISM |
| مستخلص: |
Arteriovenous difference and tracer ([3-³H]glucose) techniques were used in 42-h-fasted conscious dogs to identify any insulin-like effects of intraportally administered glucagonlike peptide 1-(7-36)amide (GLP-1). Each study consisted of an equilibration, a basal, and three 90-min test periods (P1, P2, and P3) during which somatostatin, intraportal insulin (3-fold basal) and glucagon (basal), and peripheral glucose were infused. Saline was infused intraportally in P1. During P2 and P3, GLP-1 was infused intraportally at 0.9 and 5.1 pmol·kg[sup -1]· min[sup -1] in eight dogs, at 10 and 20 pmol·kg[sup -1]·min[sup -1] in seven dogs, and at 0 pmol·kg[sup -1]·min[sup -1] in eight dogs (control group). Net hepatic glucose uptake was significantly enhanced during GLP-1 infusion at 20 pmol·kg[sup -1]·min[sup -1] [21.8 vs. 13.4 µmol· kg[sup -1]·min[sup -1] (control), P < 0.05]. Glucose utilization was significantly increased during infusion at 10 and 20 pmol·kg[sup -1]· min[sup -1] [87.3 ± 8.3 and 105.3 ± 12.8, respectively, vs. 62.2 ± 5.3 and 74.7 ± 7.4 µmol·kg[sup -1]·min[sup -1] (control), P < 0.05]. The glucose infusion rate required to maintain hyperglycemia was increased (P < 0.05) during infusion of GLP-1 at 5.1, 10, and 20 pmol·kg[sup -1]·min[sup -1] (22, 36, and 32%, respectively, greater than control). Nonhepatic glucose uptake increased significantly during delivery of GLP-1 at 5.1 and 10 pmol·kg[sup -1]·min[sup -1] (25 and 46% greater than control) and tended (P = 0.1) to increase during GLP-1 infusion at 20 pmol·kg[sup -1]·min[sup -1] (24% greater than control). Intraportal infusion of GLP-1 at high physiological and pharmacological rates increased glucose disposal primarily in nonhepatic tissues. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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