التفاصيل البيبلوغرافية
| العنوان: |
The food intake-suppressive effects of glucagon-like peptide-1 receptor signaling in the ventral tegmental area are mediated by AMPA/kainate receptors. |
| المؤلفون: |
Mietlicki-Baase, Elizabeth G., Ortinski, Pavel I., Rupprecht, Laura E., Olivos, Diana R., Alhadeff, Amber L., Pierce, R. Christopher, Hayes, Matthew R. |
| المصدر: |
American Journal of Physiology: Endocrinology & Metabolism; Dec2013, Vol. 305 Issue 11, pE1367-E1374, 8p |
| مصطلحات موضوعية: |
GLUCAGON-like peptide-1 receptor, INGESTION, CELLULAR signal transduction, AMPA receptors, EXCITATORY amino acid agents, DOPAMINE |
| مستخلص: |
The food intake-suppressive effects of glucagon-like peptide-1 receptor signaling in the ventral tegmental area are mediated by AMPA/kainate receptors. Am J Physiol Endocrinol Metab 305: E1367-E1374, 2013. First published October 8, 2013; doi:10.1152/ajpendo.00413.2013.--Glucagon-like peptide-1 receptor (GLP-1R) activation in the ventral tegmental area (VTA) is physiologically relevant for the control of palatable food intake. Here, we tested whether the food intake-suppressive effects of VTA GLP-1R activation are mediated by glutamatergic signaling within the VTA. Intra-VTA injections of the GLP-1R agonist exendin- 4 (Ex-4) reduced palatable high-fat food intake in rats primarily by reducing meal size; these effects were mediated in part via glutamatergic AMPA/kainate but not NMDA receptor signaling. Additional behavioral data indicated that GLP-1R expressed specifically within the VTA can partially mediate the intake- and body weightsuppressive effects of systemically administered Ex-4, offering the intriguing possibility that this receptor population may be clinically relevant for food intake control. Intra-VTA Ex-4 rapidly increased tyrosine hydroxylase levels within the VTA, suggesting that GLP-1R activation modulates VTA dopaminergic signaling. Further evidence for this hypothesis was provided by electrophysiological data showing that Ex-4 increased the frequency of AMPA-mediated currents and reduced the paired/pulse ratio in VTA dopamine neurons. Together, these data provide novel mechanisms by which GLP-1R agonists in the mesolimbic reward system control for palatable food intake. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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