التفاصيل البيبلوغرافية
| العنوان: |
Involvement of the vagus nerves in the regulation of basal hepatic glucose production in conscious dogs. |
| المؤلفون: |
Cardin, Sylvain, Walmsley, Konstantin, Neal, Doss W., Williams, Phillip E., Cherrington, Alan D. |
| المصدر: |
American Journal of Physiology: Endocrinology & Metabolism; Nov2002, Vol. 46 Issue 5, pE958, 7p, 3 Charts, 5 Graphs |
| مصطلحات موضوعية: |
VAGUS nerve, METABOLISM, GLUCAGON, SOMATOSTATIN |
| مستخلص: |
We determined if blocking transmission in the fibers of the vagus nerves would affect basal hepatic glucose metabolism in the 18-h-fasted conscious dog. A pancreatic clamp (somatostatin, basal portal insulin, and glucagon) was employed. A 40-min control period was followed by a 90-min test period. In one group, stainless steel cooling coils (Sham, n = 5) were perfused with a 37°C solution, while in the other (Cool, n -- 6), the coils were perfused with -20°C solution. Vagal blockade was verified by heart rate change (80 ± 9 to 84 ± 14 beats/min in Sham; 98 ± 12 to 193 ± 22 beats/min in Cool). The arterial glucose level was kept euglycemic by glucose infusion. No change in tracer-determined glucose production occurred in Sham, whereas in Cool it dropped significantly (2.4 ± 0.4 to 1.9 ± 0.4 mg · kg[SUP-1] · min[SUP-1]). Net hepatic glucose output did not change in Sham but decreased from 1.9 ± 0.3 to 1.3 ± 0.3 mg·[SUP-1] · kg[SUP-1].min[SUP-1] in the Cool group. Hepatic gluconeogenesis did not change in either group. These data suggest that vagal blockade acutely modulates hepatic glucose production by inhibiting glycogenolysis. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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