التفاصيل البيبلوغرافية
| العنوان: |
Tuberculin-Specific T Cells Are Reduced in Active Pulmonary Tuberculosis Compared to LTBI or Status Post BCG Vaccination. |
| المؤلفون: |
Streitz, Mathias, Fuhrmann, Stephan, Powell, Fiona, Quassem, Ali, Nomura, Laurel, Maecker, Holden, Martus, Peter, Volk, Hans-Dieter, Kern, Florian |
| المصدر: |
Journal of Infectious Diseases; 2/1/2011, Vol. 203 Issue 3, p378-382, 5p |
| مصطلحات موضوعية: |
T cells, MYCOBACTERIUM tuberculosis, TUMOR necrosis factors, INTERLEUKIN-2, INTERFERONS, BACTERIAL antigens, BCG vaccines |
| مستخلص: |
Functional characteristics of tuberculosis (TB)-specific CD4 T cells were studied in clinically active pulmonary TB (n = 21) and high TB exposure including LTBI (n = 17). Following tuberculin stimulation, activated CD4 T cells were identified by flow-cytometry (CD154 up-regulation, degranulation, interferon γ [IFN-γ], tumor necrosis factor α [TNF-α], and interleukin 2 [IL-2\ production). Interestingly, CD154 up-regulation accounted for ≈80% of activated CD4 T cells in the active TB group but just 40% in the controls, whereas IFN-c accounted for only ≈50% of activated cells in each group. The frequencies of CD4 T cells displaying at least 1 activation marker discriminated better between the groups than those displaying degranulation or IFN-γ production alone. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
