التفاصيل البيبلوغرافية
| العنوان: |
Cardiac Autonomic Function Correlates with Arterial Stiffness in the Early Stage of Type 1 Diabetes. |
| المؤلفون: |
Liatis, S., Alexiadou, K., Tsiakou, A., Makrilakis, K., Katsilambros, N., Tentolouris, N. |
| المصدر: |
Experimental Diabetes Research; 2011, Special section p1-7, 7p, 4 Charts, 1 Graph |
| مصطلحات موضوعية: |
DIABETES complications, HYPERTENSION, KIDNEY diseases, HEART disease research, HEART beat |
| مستخلص: |
Arterial stiffness is increased in type 1 diabetes (T1D), before any clinical complications of the disease are evident. The aim of the present paper was to investigate the association between cardiac autonomic function and arterial stiffness in a cohort of young T1D patients, without history of hypertension and any evidence of macrovascular and/or renal disease. Large artery stiffness was assessed by measurement of carotid-femoral pulse wave velocity (PWV). Cardiac autonomic function was assessed by the cardiovascular tests proposed by Ewing and Clarke. Patients with a high cardiac autonomic neuropathy score (≤4) had significantly higher PWV than those with a low score (0-1). A negative, heart rate-independent, correlation between PWV and heart rate variation during respiration was observed (r = -0.533, P < 0.001). In multivariable analysis, E/I index was the strongest correlate of PWV (β-coefficient = -0.326, P = 0.002). Cardiac parasympathetic function is a strong predictor of large arterial stiffness, in young T1D patients free of macrovascular and renal complications. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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